The course of pregnancy and childbirth in three mothers with recessive dystrophic epidermolysis bullosa

T. Hanafusa, K. Tamai, N. Umegaki, Y. Yamaguchi, S. Fukuda, Y. Nishikawa, N. Yaegashi, R. Okuyama, J. A. McGrath, I. Katayama

研究成果: Article査読

12 被引用数 (Scopus)

抄録

Background. Recessive dystrophic epidermolysis bullosa (RDEB) is an autosomal recessive skin disease caused by mutations in the type VII collagen gene (COL7A1), resulting in detachment of the entire epidermis due to loss or hypoplasticity of the anchoring fibrils that normally secure the basement membrane to the underlying dermis. Trauma-induced blistering is often complicated by chronic erosions and scarring. From that perspective, pregnancy in RDEB might be considered an indication for elective caesarean section in a bid to minimize perineal blistering. To date, only four cases of pregnancy and delivery in patients with RDEB have been reported. Cases. We report three more women, each with RDEB-generalized other (RDEB-GO), all of whom had successful vaginal deliveries without major cutaneous or mucosal complications. One woman also had a second child, by vaginal delivery, indicating a lack of vaginal stenosis after the first birth. Conclusions. These cases show that RDEB-GO is not an absolute primary indication for elective caesarean section and that, perhaps surprisingly, genital/perineal blistering and scarring are not inevitable consequences of childbirth. Moreover, breastfeeding is also feasible in women with RDEB-GO.

本文言語English
ページ(範囲)10-14
ページ数5
ジャーナルClinical and Experimental Dermatology
37
1
DOI
出版ステータスPublished - 2012 1月
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ASJC Scopus subject areas

  • 皮膚病学

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