TY - JOUR
T1 - The effect of superficial tissue of the head on spatial sensitivity profiles for near infrared spectroscopy and imaging
AU - Okada, Eiji
PY - 2000
Y1 - 2000
N2 - Near infrared spectroscopy and imaging have been used in measurements of brain activity. The scatter of light in biological tissue which causes ambiguity in the volume of tissue interrogated with near infrared instruments is a serious problem for near infrared spectroscopy and imaging. The heterogeneity of superficial tissue of the head, especially the presence of non-scattering clear cerebrospinal fluid, affects the light propagation in the brain. In this paper the theoretical results of the effect of superficial tissue on the spatial sensitivity profile in the head for near infrared spectroscopy and imaging are reviewed. Simplified homogeneous and heterogeneous models are used to investigate the effect of the non-scattering clear layer on the spatial sensitivity profile in the head. Time resolved spatial sensitivity profiles reveal the effect of this layer on the early and late detected light. Finally, the author presents the spatial sensitivity profiles in the sophisticated adult and neonate head models to discuss the effect of superficial tissue on the near infrared measurement of brain activity in the two heads.
AB - Near infrared spectroscopy and imaging have been used in measurements of brain activity. The scatter of light in biological tissue which causes ambiguity in the volume of tissue interrogated with near infrared instruments is a serious problem for near infrared spectroscopy and imaging. The heterogeneity of superficial tissue of the head, especially the presence of non-scattering clear cerebrospinal fluid, affects the light propagation in the brain. In this paper the theoretical results of the effect of superficial tissue on the spatial sensitivity profile in the head for near infrared spectroscopy and imaging are reviewed. Simplified homogeneous and heterogeneous models are used to investigate the effect of the non-scattering clear layer on the spatial sensitivity profile in the head. Time resolved spatial sensitivity profiles reveal the effect of this layer on the early and late detected light. Finally, the author presents the spatial sensitivity profiles in the sophisticated adult and neonate head models to discuss the effect of superficial tissue on the near infrared measurement of brain activity in the two heads.
KW - Biomedical optics
KW - Cerebrospinal fluid
KW - Monte Carlo simulation
KW - Near infrared imaging
KW - Near infrared spectroscopy
KW - Photon migration
KW - Spatial sensitivity profiles
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U2 - 10.1007/s10043-000-0375-4
DO - 10.1007/s10043-000-0375-4
M3 - Article
AN - SCOPUS:0034346619
SN - 1340-6000
VL - 7
SP - 375
EP - 382
JO - Optical Review
JF - Optical Review
IS - 5
ER -