The expression of granulysin in systemic anaplastic large cell lymphoma in childhood

Noriko Kitamura, Yohko U. Katagiri, Mitsuko Itagaki, Yoshitaka Miyagawa, Keiko Onda, Hajime Okita, Akio Mori, Junichiro Fujimoto, Nobutaka Kiyokawa

研究成果: Article査読

12 被引用数 (Scopus)

抄録

The expression of granulysin, a cytolytic protein produced by activated T and NK cells, has been revealed to be correlated with the prognosis of some adult cancer patients. By examination on various childhood lymphoma tissues, we found that granulysin level was especially high in systemic anaplastic large cell lymphoma (ALCL) cases, whereas no close correlation with the expression of CD96, a marker for activated T and NK cells, was observed. We further demonstrated that both ALCL cells in biopsy specimens and cell lines established from ALCL express granulysin, indicating some correlation of granulysin with biological features of ALCL.

本文言語English
ページ(範囲)908-912
ページ数5
ジャーナルLeukemia Research
33
7
DOI
出版ステータスPublished - 2009 7月
外部発表はい

ASJC Scopus subject areas

  • 血液学
  • 腫瘍学
  • 癌研究

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