TY - JOUR
T1 - The fifth exon of the myelin proteolipid protein-coding gene is not utilized in the brain of jimpy mutant mice
AU - Moriguchi, Akira
AU - Ikenaka, Kazuhiro
AU - Furuichi, Teiichi
AU - Okano, Hideyuki
AU - Iwasaki, Yasuno
AU - Mikoshiba, Katsuhiko
PY - 1987
Y1 - 1987
N2 - The jimpy mouse, an X-linked recessive dysmyelinating and demyelinating mutant, has been shown to contain abnormal myelin proteolipid protein (PLP) mRNA. To understand the molecular basis of the mutation, we analyzed the structure of PLP mRNA by an RNase-mapping procedure, using the probes specific to each exon of the mouse PLP gene. We found that the fifth exon of the PLP gene is not utilized in the jimpy.
AB - The jimpy mouse, an X-linked recessive dysmyelinating and demyelinating mutant, has been shown to contain abnormal myelin proteolipid protein (PLP) mRNA. To understand the molecular basis of the mutation, we analyzed the structure of PLP mRNA by an RNase-mapping procedure, using the probes specific to each exon of the mouse PLP gene. We found that the fifth exon of the PLP gene is not utilized in the jimpy.
KW - Pelizaeus-Merzbacher disease
KW - RNase A and T1 mapping
KW - X-linked
KW - myelin deficiency
KW - oligodendrocytes
KW - phage vectors
KW - recombinant DNA
UR - http://www.scopus.com/inward/record.url?scp=0023064415&partnerID=8YFLogxK
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U2 - 10.1016/0378-1119(87)90293-9
DO - 10.1016/0378-1119(87)90293-9
M3 - Article
C2 - 2444499
AN - SCOPUS:0023064415
SN - 0378-1119
VL - 55
SP - 333
EP - 337
JO - Gene
JF - Gene
IS - 2-3
ER -