TY - CHAP
T1 - The loss of Foxc2 expression in the outflow tract links the interrupted arch in the conditional Foxc2 knockout mouse
AU - Uddin, Mohammad Khaja Mafij
AU - Kimura, Wataru
AU - Amin, Mohammed Badrul
AU - Nakamura, Kasumi
AU - Islam, Mohammod Johirul
AU - Yamagishi, Hiroyuki
AU - Miura, Naoyuki
N1 - Publisher Copyright:
© The Author(s) 2016.
Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Congenital heart disease is the most common birth defects, affecting 1 % live births [1]. The cardiovascular system undergoes a series of morphogenetic events to form a heart and an aorta in fetuses. Formation of the heart and aorta requires migration, differentiation, and precise interactions among multiple cells from several embryonic origins [2]. Forkhead box2 (Foxc2) encodes a transcription factor and is expressed in mesodermal tissues, such as the pharyngeal artery, outflow tract endothelial/surrounding mesenchyme, bone, and kidney [3]. Simple knockout of Foxc2 in mouse causes an interrupted aortic arch, ventricular septal defect, cleft palate, and skeletal malformation [4]. The heart is made from primary and secondary heart field progenitors. The primary heart field gives rise to the left ventricle and atria, while the secondary heart field contributes mainly to the right ventricle and outflow tract [5] (Fig. 27.1).
AB - Congenital heart disease is the most common birth defects, affecting 1 % live births [1]. The cardiovascular system undergoes a series of morphogenetic events to form a heart and an aorta in fetuses. Formation of the heart and aorta requires migration, differentiation, and precise interactions among multiple cells from several embryonic origins [2]. Forkhead box2 (Foxc2) encodes a transcription factor and is expressed in mesodermal tissues, such as the pharyngeal artery, outflow tract endothelial/surrounding mesenchyme, bone, and kidney [3]. Simple knockout of Foxc2 in mouse causes an interrupted aortic arch, ventricular septal defect, cleft palate, and skeletal malformation [4]. The heart is made from primary and secondary heart field progenitors. The primary heart field gives rise to the left ventricle and atria, while the secondary heart field contributes mainly to the right ventricle and outflow tract [5] (Fig. 27.1).
KW - Conditional knockout
KW - Foxc2
KW - Interruption of aortic arch
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U2 - 10.1007/978-4-431-54628-3_27
DO - 10.1007/978-4-431-54628-3_27
M3 - Chapter
AN - SCOPUS:85006784849
SN - 9784431546276
SP - 211
EP - 213
BT - Etiology and Morphogenesis of Congenital Heart Disease
PB - Springer Japan
ER -