The lysosome rupture-activated TAK1-JNK pathway regulates NLRP3 inflammasome activation

Masahiro Okada; Atsushi Matsuzawa; Akihiko Yoshimura; Hidenori Ichijo

doi:10.1074/jbc.M114.579961

The lysosome rupture-activated TAK1-JNK pathway regulates NLRP3 inflammasome activation

Masahiro Okada, Atsushi Matsuzawa, Akihiko Yoshimura, Hidenori Ichijo

微生物学・免疫学

研究成果: Article › 査読

148 被引用数 (Scopus)

抄録

Results: Inhibition of CaMKII, TAK1, or JNK specifically suppressed lysosome rupture-induced NLRP3 inflammasome activation.

Background: The mechanisms underlying lysosome rupture-mediated inflammasome activation are not understood.

Conclusion: Activation of the Ca²⁺-CaMKII-TAK1-JNK pathway in lysosome rupture is necessary for complete activation of the NLRP3 inflammasome.

Significance: Our results suggest novel roles for the Ca²⁺-CaMKII-TAK1-JNK pathway in the regulation of the inflammasome and propose potential therapeutic targets for inflammatory diseases.

本文言語	English
ページ（範囲）	32926-32936
ページ数	11
ジャーナル	Journal of Biological Chemistry
巻	289
号	47
DOI	https://doi.org/10.1074/jbc.M114.579961
出版ステータス	Published - 2014 11月 21

ASJC Scopus subject areas

生化学
分子生物学
細胞生物学

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abstract = "Results: Inhibition of CaMKII, TAK1, or JNK specifically suppressed lysosome rupture-induced NLRP3 inflammasome activation.Background: The mechanisms underlying lysosome rupture-mediated inflammasome activation are not understood.Conclusion: Activation of the Ca2+-CaMKII-TAK1-JNK pathway in lysosome rupture is necessary for complete activation of the NLRP3 inflammasome.Significance: Our results suggest novel roles for the Ca2+-CaMKII-TAK1-JNK pathway in the regulation of the inflammasome and propose potential therapeutic targets for inflammatory diseases.",

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AB - Results: Inhibition of CaMKII, TAK1, or JNK specifically suppressed lysosome rupture-induced NLRP3 inflammasome activation.Background: The mechanisms underlying lysosome rupture-mediated inflammasome activation are not understood.Conclusion: Activation of the Ca2+-CaMKII-TAK1-JNK pathway in lysosome rupture is necessary for complete activation of the NLRP3 inflammasome.Significance: Our results suggest novel roles for the Ca2+-CaMKII-TAK1-JNK pathway in the regulation of the inflammasome and propose potential therapeutic targets for inflammatory diseases.

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The lysosome rupture-activated TAK1-JNK pathway regulates NLRP3 inflammasome activation

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