The Mechanism of Iron(II)-Catalyzed Asymmetric Mukaiyama Aldol Reaction in Aqueous Media: Density Functional Theory and Artificial Force-Induced Reaction Study

Chemical Compounds

• Mukaiyama Aldol Addition 80%
• Aldehyde 38%
• Trimethylsilyl Group 37%
• Density Functional Theory 34%
• Diastereoselectivity 27%
• Proton Transfer 24%
• Enantioselectivity 23%
• Multicomponent Reaction 23%
• Transition State 22%
• Ground State 21%
• Transition Element 19%
• Dissociation 19%

Medicine & Life Sciences

• 3-hydroxybutanal 100%
• Density Functional Theory 95%
• Carbon 54%
• Iron 45%
• Aldehydes 21%
• Protons 9%
• Metals 7%
• Water 6%

Engineering & Materials Science

• Density functional theory 81%
• Iron 49%
• Carbon 41%
• Aldehydes 26%
• Enantioselectivity 18%
• Proton transfer 16%
• Ground state 13%
• Transition metals 13%
• Water 4%
• Experiments 3%