The prognosis of patients with hepatocellular carcinoma of multicentric origin

Takuji Okusaka, Shuichi Okada, Haruhiko Nose, Hiroshi Ishii, Hidekazu Nakasuka, Hidetsugu Nakayama, Hiroyasu Nagahama, Masayoshi Yoshimori, Kazuaki Shimada, Junji Yamamoto, Tadatoshi Takayama, Tomoo Kosuge, Susumu Yamasaki, Michiie Sakamoto, Setsuo Hirohashi

研究成果: Article査読

20 被引用数 (Scopus)


Background/Aims: The characteristics of patients with multicentric hepatocellular carcinoma (HCC) differ from those of patients with intrahepatic metastatic HCC. However, there are few reports regarding the long-term results in patients with HCC of multicentric occurrence. The purpose of this study was to clarify the prognosis of a group of patients with multicentric HCCs. Materials and Methods: We evaluated the outcome in 28 patients with multiple hepatocellular carcinoma (HCC) suggestive of multicentric occurrence, all of whom underwent hepatic resection. The disease-free survival, recurrence pattern and survival were analyzed in the two subgroups of 12 patients with single advanced HCC (AdHCC) nodule and an early HCC (eHCC) or early advanced HCC (eAdHCC) nodule [Group A] and 16 patients with two AdHCC lesions [Group B]. These data were also compared with those of 58 patients with solitary AdHCC [Group C]. Results: Both the disease-free survival and survival periods for Groups A and C were significantly longer than those for Group B, while no significant difference was seen between Group A and C. No significant differences among the three groups were recognized in the incidence of various types of recurrence pattern. Conclusions: The long-term results in patients with multicentric HCC apparently vary depending on the pathological condition at the time of operation. Among patients with multicentric HCC, those with AdHCC combined with an eHCC or eAdHCC are likely to show improved prognosis as a result of hepatic resection.

出版ステータスPublished - 1996

ASJC Scopus subject areas

  • 肝臓学
  • 消化器病学


「The prognosis of patients with hepatocellular carcinoma of multicentric origin」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。