The Role of Animal Models in Elucidating the Etiology and Pathology of Abdominal Aortic Aneurysms: Development of a Novel Rupture Mechanism Model

Hiroki Tanaka; Nobuhiro Zaima; Hirona Kugo; Tatsuro Yata; Yasunori Iida; Keisuke Hashimoto; Chie Miyamoto; Takeshi Sasaki; Hideto Sano; Yuko Suzuki; Tatsuya Moriyama; Hideyuki Shimizu; Kazunori Inuzuka; Tetsumei Urano; Naoki Unno

doi:10.1016/j.avsg.2019.08.082

The Role of Animal Models in Elucidating the Etiology and Pathology of Abdominal Aortic Aneurysms: Development of a Novel Rupture Mechanism Model

Hiroki Tanaka, Nobuhiro Zaima, Hirona Kugo, Tatsuro Yata, Yasunori Iida, Keisuke Hashimoto, Chie Miyamoto, Takeshi Sasaki, Hideto Sano, Yuko Suzuki, Tatsuya Moriyama, Hideyuki Shimizu, Kazunori Inuzuka, Tetsumei Urano, Naoki Unno

外科学(心臓血管)

研究成果: Review article › 査読

5 被引用数 (Scopus)

抄録

Existing animal models do not replicate all aspects of abdominal aortic aneurysms (AAAs), including the rupture mechanisms. From histopathological analyses conducted in humans, it has been found that the vasa vasorum of the AAA wall is the starting point of circulatory failure and that bulging and dilatation of the abdominal aorta occurs through inflammation and tissue degeneration. We created a new animal model (the hypoperfusion-induced model) of AAAs. In this study, we describe the current animal models of AAAs and present the utility of our new model of AAAs.

本文言語	English
ページ（範囲）	382-390
ページ数	9
ジャーナル	Annals of Vascular Surgery
巻	63
DOI	https://doi.org/10.1016/j.avsg.2019.08.082
出版ステータス	Published - 2020 2月

ASJC Scopus subject areas

外科
循環器および心血管医学

文献へのアクセス

10.1016/j.avsg.2019.08.082

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引用スタイル

Tanaka, H., Zaima, N., Kugo, H., Yata, T., Iida, Y., Hashimoto, K., Miyamoto, C., Sasaki, T., Sano, H., Suzuki, Y., Moriyama, T., Shimizu, H., Inuzuka, K., Urano, T., & Unno, N. (2020). The Role of Animal Models in Elucidating the Etiology and Pathology of Abdominal Aortic Aneurysms: Development of a Novel Rupture Mechanism Model. Annals of Vascular Surgery, 63, 382-390. https://doi.org/10.1016/j.avsg.2019.08.082

Tanaka, H, Zaima, N, Kugo, H, Yata, T, Iida, Y, Hashimoto, K, Miyamoto, C, Sasaki, T, Sano, H, Suzuki, Y, Moriyama, T, Shimizu, H, Inuzuka, K, Urano, T & Unno, N 2020, 'The Role of Animal Models in Elucidating the Etiology and Pathology of Abdominal Aortic Aneurysms: Development of a Novel Rupture Mechanism Model', Annals of Vascular Surgery, vol. 63, pp. 382-390. https://doi.org/10.1016/j.avsg.2019.08.082

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