TY - JOUR
T1 - The role of blood-ocular barrier transporters in retinal drug disposition
T2 - An overview
AU - Tomi, Masatoshi
AU - Hosoya, Ken Ichi
N1 - Funding Information:
The authors’ work on transport mechanisms at the BRB is supported, in part, by a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science (JSPS).
PY - 2010/9
Y1 - 2010/9
N2 - Importance of the field: Delivery of drugs to the retina remains a major challenge which needs to be addressed urgently because retinal disorders are leading causes of visual impairment and significantly affect a patient's quality of life. Systemic drug administration is one possible route for treating retinal disorders; however, retinal transfer of drugs from the circulating blood is strictly regulated by two bloodocular barrier systems, the bloodaqueous barrier and the bloodretinal barrier. Areas covered in this review: This review summarizes the latest biological research regarding bloodocular barrier drug transporters. What the reader will gain: The bloodocular barrier sites and their respective roles in aqueous humor dynamics and retinal homeostasis are briefly presented. The potential impact of ATP-binding cassette (ABC) and solute carrier (SLC) drug transporters, such as ABCB, ABCC, ABCG, SLC7, SLC16, SLC19, SLCO/SLC21A, SLC22A and SLC29 transporters, on the permeability of drugs across the bloodocular barriers is then illustrated. Take home message: As more information becomes available regarding the bloodocular barrier transporters, we may be able to design simpler and more effective routes for drug delivery to the retina and, consequently, improve the treatment of retinal diseases.
AB - Importance of the field: Delivery of drugs to the retina remains a major challenge which needs to be addressed urgently because retinal disorders are leading causes of visual impairment and significantly affect a patient's quality of life. Systemic drug administration is one possible route for treating retinal disorders; however, retinal transfer of drugs from the circulating blood is strictly regulated by two bloodocular barrier systems, the bloodaqueous barrier and the bloodretinal barrier. Areas covered in this review: This review summarizes the latest biological research regarding bloodocular barrier drug transporters. What the reader will gain: The bloodocular barrier sites and their respective roles in aqueous humor dynamics and retinal homeostasis are briefly presented. The potential impact of ATP-binding cassette (ABC) and solute carrier (SLC) drug transporters, such as ABCB, ABCC, ABCG, SLC7, SLC16, SLC19, SLCO/SLC21A, SLC22A and SLC29 transporters, on the permeability of drugs across the bloodocular barriers is then illustrated. Take home message: As more information becomes available regarding the bloodocular barrier transporters, we may be able to design simpler and more effective routes for drug delivery to the retina and, consequently, improve the treatment of retinal diseases.
KW - ABC transporters
KW - Bloodaqueous barrier
KW - Bloodocular barrier
KW - Bloodretinal barrier
KW - Drug transporters
KW - Retina
KW - SLC transporters
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U2 - 10.1517/17425255.2010.486401
DO - 10.1517/17425255.2010.486401
M3 - Review article
C2 - 20438316
AN - SCOPUS:77955796725
SN - 1742-5255
VL - 6
SP - 1111
EP - 1124
JO - Expert Opinion on Drug Metabolism and Toxicology
JF - Expert Opinion on Drug Metabolism and Toxicology
IS - 9
ER -