@article{05768a553b1a4443b4eb0b459bdca293,
title = "The role of Cbln1 on Purkinje cell synapse formation",
abstract = "Cbln1 is a glycoprotein which belongs to the C1q family. In the cerebellum, Cbln1 is produced and secreted from granule cells and works as a strong synapse organizer between Purkinje cells and parallel fibers, the axons of the granule cells. In this update article, we will describe the molecular mechanisms by which Cbln1 induces synapse formation and will review our findings on the axonal structural changes which occur specifically during this process. We will also describe our recent finding that Cbln1 has a suppressive role in inhibitory synapse formation between Purkinje cells and molecular layer interneurons. Our results have revealed that Cbln1 plays an essential role to establish parallel fiber-Purkinje cell synapses and to regulate balance between excitatory and inhibitory input on Purkinje cells.",
keywords = "Cbln1, Cerebellum, Purkinje cell, Synapse formation",
author = "Aya Ito-Ishida and Shigeo Okabe and Michisuke Yuzaki",
note = "Funding Information: This research has been supported by the Core Research for Evolutional Science and Technology from the Japan Science and Technology Agency (M.Y.), Grants-in-Aid for Scientific Research (KAKENHI) from the Ministry of Education, Culture, Sports, Science, and Technology of Japan, grant numbers 21220008 (S.O.) and 23110009 (M.Y.), and Grant-in-aid Japan Society for the Promotion of Science (JSPS) fellows (A.I-I.). We would like to thank Dr. Kerstin Ure (Baylor College of Medicine) for discussion and critical comments on the manuscript. Publisher Copyright: {\textcopyright} 2014 Elsevier Ireland Ltd and the Japan Neuroscience Society.",
year = "2014",
month = jun,
day = "1",
doi = "10.1016/j.neures.2014.01.009",
language = "English",
volume = "83",
pages = "64--68",
journal = "Neuroscience Research",
issn = "0168-0102",
publisher = "Elsevier Ireland Ltd",
}