The role of matrix metalloproteinases in glioma invasion.

Mitsutoshi Nakada, Yasunori Okada, Junkoh Yamashita

研究成果: Review article査読

95 被引用数 (Scopus)


The matrix metalloproteinase (MMP) family plays an important role in the degradation of extracellular matrix (ECM) in various physiological and pathological conditions. Accumulated evidence has suggested that MMPs contribute to cancer cell invasion of the surrounding normal tissues and metastasis through the cell-surface ECM degradation. Strong correlations have been reported between elevated MMP levels and tumor cell invasiveness in human gliomas. Among them, attention has been focused on gelatinases (MMP-2 and MMP-9) and membrane type MMPs (MT-MMPs). We discuss here the biological significance of these MMPs in the glioblastoma invasion processes. A better understanding of cell-ECM interactions will help in developing therapeutic strategies to decrease the invasion of gliomas.

ジャーナルFrontiers in bioscience : a journal and virtual library
出版ステータスPublished - 2003 1月 1

ASJC Scopus subject areas

  • 生化学、遺伝学、分子生物学一般
  • 免疫学および微生物学一般


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