TY - JOUR
T1 - The Role of Surgery in Advanced Neuroblastoma
AU - Yokoyama, J.
AU - Ikawa, H.
AU - Endow, M.
AU - Fuchimoto, Y.
AU - Watanabe, K.
AU - Hosoya, R.
AU - Nishimura, K.
PY - 1995/2
Y1 - 1995/2
N2 - Recently we performed multi-modal therapy including chemotherapy with bone marrow transplantation (BMT), surgery, and local irradiation in the treatment of advanced neuroblastoma. As a result, all Stage III patients survived, and 4 out of 8 Stage IV patients who underwent our original systemic gross complete resection achieved long-term survival, 4y 8m, 5y 8m, 5y 6m and 5y 5m, respectively. Long-term survival patients were treated by local irradiation, brain surgery and intensive induction chemotherapy before primary site operation, and when resolution of distant metastases was obtained, the primary site was resected completely, followed by postoperative supralethal chemotherapy with BMT. The purpose of this report is to elucidate the role of surgery in advanced neuroblastoma based on our clinical results.
AB - Recently we performed multi-modal therapy including chemotherapy with bone marrow transplantation (BMT), surgery, and local irradiation in the treatment of advanced neuroblastoma. As a result, all Stage III patients survived, and 4 out of 8 Stage IV patients who underwent our original systemic gross complete resection achieved long-term survival, 4y 8m, 5y 8m, 5y 6m and 5y 5m, respectively. Long-term survival patients were treated by local irradiation, brain surgery and intensive induction chemotherapy before primary site operation, and when resolution of distant metastases was obtained, the primary site was resected completely, followed by postoperative supralethal chemotherapy with BMT. The purpose of this report is to elucidate the role of surgery in advanced neuroblastoma based on our clinical results.
KW - Bone marrow transplantation
KW - Intensive chemotherapy
KW - Neuroblastoma
KW - Surgery
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U2 - 10.1055/s-2008-1066156
DO - 10.1055/s-2008-1066156
M3 - Article
C2 - 7756229
AN - SCOPUS:0028937959
SN - 0939-7248
VL - 5
SP - 23
EP - 26
JO - European Journal of Pediatric Surgery
JF - European Journal of Pediatric Surgery
IS - 1
ER -