The synthesis and biological activity of pyranonaphthoquione derivatives from Streptomyces sp. and their related substances

Akiko Shimbashi, Ayako Tsuchiya, Masaya Imoto, Shigeru Nishiyama

研究成果: Article査読

7 被引用数 (Scopus)

抄録

The total synthesis of a novel pyranonaphthoquinone (2) having Cdc25A phosphatase inhibitory activity is achieved. The key step in this synthetic pathway is the intramolecular Michael addition for construction of the pyran ring system. The inhibitory activity of several derivatives, readily obtained from synthetic intermediates of 2, is assessed. The resulting data indicates that the pyran ring moiety is not a crucial factor for the activity.

本文言語English
ページ(範囲)1925-1930
ページ数6
ジャーナルBulletin of the Chemical Society of Japan
77
10
DOI
出版ステータスPublished - 2004 10月

ASJC Scopus subject areas

  • 化学一般

フィンガープリント

「The synthesis and biological activity of pyranonaphthoquione derivatives from Streptomyces sp. and their related substances」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル