Therapeutic activity of 1-β-D-arabinofuranosylcytosine conjugates of lipids in WEHI-3B leukemia in mice

W. E. Berdel; S. Okamoto; S. Danhauser-Riedl; C. I. Hong; E. F. Winton; C. R. West; J. Rastetter; W. R. Vogler

Therapeutic activity of 1-β-D-arabinofuranosylcytosine conjugates of lipids in WEHI-3B leukemia in mice

W. E. Berdel, S. Okamoto, S. Danhauser-Riedl, C. I. Hong, E. F. Winton, C. R. West, J. Rastetter, W. R. Vogler

研究成果: Article › 査読

抄録

Two new conjugates of 1-β-arabinofuranosylcytosine (ara-C) and lipids were tested for therapeutic activity in myelomonocytic WEHI-3B leukemia in mice. Both conjugates were superior to equimolar mixtures of their respective parent compounds and to ara-C alone. IP treatment was found effective after either IP or IV transplantation of the leukemia. The thioether-linked lipid conjugate ara-CDP-D,L-PTBA showed considerably higher efficacy than the ester-linked lipid conjugate ara-CDP-L-dipalmitin. The optimal therapeutic regimen of ara-CDP-D,L-PTBA consisted of 60 mg/kg given IP qd 1-5 after transplantation of the WEHI-3B leukemia.

本文言語	English
ページ（範囲）	364-367
ページ数	4
ジャーナル	Experimental Hematology
巻	17
号	4
出版ステータス	Published - 1989
外部発表	はい

ASJC Scopus subject areas

分子生物学
血液学
遺伝学
細胞生物学
癌研究

UN SDG

この成果は、次の持続可能な開発目標に貢献しています

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title = "Therapeutic activity of 1-β-D-arabinofuranosylcytosine conjugates of lipids in WEHI-3B leukemia in mice",

abstract = "Two new conjugates of 1-β-arabinofuranosylcytosine (ara-C) and lipids were tested for therapeutic activity in myelomonocytic WEHI-3B leukemia in mice. Both conjugates were superior to equimolar mixtures of their respective parent compounds and to ara-C alone. IP treatment was found effective after either IP or IV transplantation of the leukemia. The thioether-linked lipid conjugate ara-CDP-D,L-PTBA showed considerably higher efficacy than the ester-linked lipid conjugate ara-CDP-L-dipalmitin. The optimal therapeutic regimen of ara-CDP-D,L-PTBA consisted of 60 mg/kg given IP qd 1-5 after transplantation of the WEHI-3B leukemia.",

author = "Berdel, {W. E.} and S. Okamoto and S. Danhauser-Riedl and Hong, {C. I.} and Winton, {E. F.} and West, {C. R.} and J. Rastetter and Vogler, {W. R.}",

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T1 - Therapeutic activity of 1-β-D-arabinofuranosylcytosine conjugates of lipids in WEHI-3B leukemia in mice

AU - Berdel, W. E.

AU - Okamoto, S.

AU - Danhauser-Riedl, S.

AU - Hong, C. I.

AU - Winton, E. F.

AU - West, C. R.

AU - Rastetter, J.

AU - Vogler, W. R.

PY - 1989

Y1 - 1989

N2 - Two new conjugates of 1-β-arabinofuranosylcytosine (ara-C) and lipids were tested for therapeutic activity in myelomonocytic WEHI-3B leukemia in mice. Both conjugates were superior to equimolar mixtures of their respective parent compounds and to ara-C alone. IP treatment was found effective after either IP or IV transplantation of the leukemia. The thioether-linked lipid conjugate ara-CDP-D,L-PTBA showed considerably higher efficacy than the ester-linked lipid conjugate ara-CDP-L-dipalmitin. The optimal therapeutic regimen of ara-CDP-D,L-PTBA consisted of 60 mg/kg given IP qd 1-5 after transplantation of the WEHI-3B leukemia.

AB - Two new conjugates of 1-β-arabinofuranosylcytosine (ara-C) and lipids were tested for therapeutic activity in myelomonocytic WEHI-3B leukemia in mice. Both conjugates were superior to equimolar mixtures of their respective parent compounds and to ara-C alone. IP treatment was found effective after either IP or IV transplantation of the leukemia. The thioether-linked lipid conjugate ara-CDP-D,L-PTBA showed considerably higher efficacy than the ester-linked lipid conjugate ara-CDP-L-dipalmitin. The optimal therapeutic regimen of ara-CDP-D,L-PTBA consisted of 60 mg/kg given IP qd 1-5 after transplantation of the WEHI-3B leukemia.

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AN - SCOPUS:0024559503

SN - 0301-472X

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Therapeutic activity of 1-β-D-arabinofuranosylcytosine conjugates of lipids in WEHI-3B leukemia in mice

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ASJC Scopus subject areas

UN SDG

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