TY - JOUR
T1 - Thermo-Responsive Polymer Brushes as Intelligent Biointerfaces
T2 - Preparation via ATRP and Characterization
AU - Nagase, Kenichi
AU - Watanabe, Minami
AU - Kikuchi, Akihiko
AU - Yamato, Masayuki
AU - Okano, Teruo
PY - 2011/3/10
Y1 - 2011/3/10
N2 - PIPAAm-brush grafted glass substrates with various graft densities and chain lengths were prepared via surface-initiated ATRP. Temperature-dependent physicochemical properties of the surfaces were characterized by means of ATR/FT-IR spectroscopy, XPS, AFM, and contact angle measurements. ATRP conditions influence the amount of grafted PIPAAm and the surface wettability and roughness of the substrate. Fibronectin adsorption and EC adhesion increased with decreasing density of PIPAAm brushes. EC adhesion was diminished with increasing PIPAAm graft length. Thus, the preparation of PIPAAm brush surface with various graft densities and chain lengths using the surface-initiated ATRP is an effective method for modulating thermo-responsive properties of surfaces. Thermo-responsive polymer brushes with various graft densities and chain lengths were prepared on glass substrates by surface-initiated ATRP. Cell adhesion and protein adsorption were enhanced with diluting polymer brush density, due to the exposure of grafted phenethyl group onto outer surfaces. These unique properties are valuable for designing novel biointerfaces.
AB - PIPAAm-brush grafted glass substrates with various graft densities and chain lengths were prepared via surface-initiated ATRP. Temperature-dependent physicochemical properties of the surfaces were characterized by means of ATR/FT-IR spectroscopy, XPS, AFM, and contact angle measurements. ATRP conditions influence the amount of grafted PIPAAm and the surface wettability and roughness of the substrate. Fibronectin adsorption and EC adhesion increased with decreasing density of PIPAAm brushes. EC adhesion was diminished with increasing PIPAAm graft length. Thus, the preparation of PIPAAm brush surface with various graft densities and chain lengths using the surface-initiated ATRP is an effective method for modulating thermo-responsive properties of surfaces. Thermo-responsive polymer brushes with various graft densities and chain lengths were prepared on glass substrates by surface-initiated ATRP. Cell adhesion and protein adsorption were enhanced with diluting polymer brush density, due to the exposure of grafted phenethyl group onto outer surfaces. These unique properties are valuable for designing novel biointerfaces.
KW - Adhesion
KW - Atom transfer radical polymerization (ATRP)
KW - Cells
KW - Polymer brushes
KW - Stimuli-sensitive polymers
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U2 - 10.1002/mabi.201000312
DO - 10.1002/mabi.201000312
M3 - Article
C2 - 21104702
AN - SCOPUS:79952093946
SN - 1616-5187
VL - 11
SP - 400
EP - 409
JO - Macromolecular Bioscience
JF - Macromolecular Bioscience
IS - 3
ER -