Thermo-responsive protein adsorbing materials for purifying pharmaceutical protein on exposed charging surface

Kenichi Nagase; Simuck F. Yuk; Jun Kobayashi; Akihiko Kikuchi; Yoshikatsu Akiyama; Hideko Kanazawa; Teruo Okano

doi:10.1039/c0jm03453c

Thermo-responsive protein adsorbing materials for purifying pharmaceutical protein on exposed charging surface

Kenichi Nagase, Simuck F. Yuk, Jun Kobayashi, Akihiko Kikuchi, Yoshikatsu Akiyama, Hideko Kanazawa, Teruo Okano

研究成果: Article › 査読

46 被引用数 (Scopus)

抄録

Thermo-responsive anionic terpolymer brushes with high selectivity for proteins were prepared though surface-initiated ATRP. Utilizing these terpolymer brushes, pure lysozyme was successfully separated from egg-white. Thus, the prepared thermo-responsive terpolymer brush is an effective separation tool for the pharmaceutical and biotechnological industries that produce valuable proteins.

本文言語	English
ページ（範囲）	2590-2593
ページ数	4
ジャーナル	Journal of Materials Chemistry
巻	21
号	8
DOI	https://doi.org/10.1039/c0jm03453c
出版ステータス	Published - 2011 2月 28
外部発表	はい

ASJC Scopus subject areas

化学 (全般)
材料化学

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10.1039/c0jm03453c

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AU - Nagase, Kenichi

AU - Yuk, Simuck F.

AU - Kobayashi, Jun

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AU - Akiyama, Yoshikatsu

AU - Kanazawa, Hideko

AU - Okano, Teruo

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AB - Thermo-responsive anionic terpolymer brushes with high selectivity for proteins were prepared though surface-initiated ATRP. Utilizing these terpolymer brushes, pure lysozyme was successfully separated from egg-white. Thus, the prepared thermo-responsive terpolymer brush is an effective separation tool for the pharmaceutical and biotechnological industries that produce valuable proteins.

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Thermo-responsive protein adsorbing materials for purifying pharmaceutical protein on exposed charging surface

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