Thermoresponsive polymer brush surfaces with hydrophobic groups for all-aqueous chromatography

Kenichi Nagase, Mio Kumazaki, Hideko Kanazawa, Jun Kobayashi, Akihiko Kikuci, Yoshikatsu Akiyama, Masahiko Annaka, Teruo Okano

研究成果: Article査読

64 被引用数 (Scopus)


For developing thermoresponsive chromatographic matrices with a strong hydrophobicity, poly(N-isopropylacrylamide-co-n-butyl methacrylate) (poly(IPAAm-co-BMA)) brush grafted silica beads were prepared through a surface-initiated atom transfer radical polymerization (ATRP) with a CuCl/CuCl2/Me6TREN catalytic system in 2-propanol at 25 °C for 16 h. The prepared beads were characterized by chromatographic analysis. Chromatograms of the benzoic-acid family and phenol as model analytes were obtained with high-resolution peaks because of their strong hydrophobic interactions to the densely grafted hydrophobized copolymers on the beads. Retention times of the analytes increased with the increase in BMA composition ratio. Dehydration of grafted copolymer with large BMA composition was performed at low temperature. These results indicated that the copolymer-brush-grafted surface prepared by ATRP was an effective tool for separating hydrophilic analytes at low temperature through modulating the strong hydrophobic interaction.

ジャーナルACS Applied Materials and Interfaces
出版ステータスPublished - 2010 4月 28

ASJC Scopus subject areas

  • 材料科学一般


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