抄録
Thermoresponsive surfaces are prepared via a spin-coating method with a block copolymer consisting of poly(N-isopropylacrylamide) (PIPAAm) and poly(butyl methacrylate) (PBMA) on polystyrene surfaces. The PBMA block suppresses the removal of deposited PIPAAm-based polymers from the surface. The polymer coating affects the temperature-dependent cellular behavior of the surfaces with respect to protein adsorption. By adjusting layer thicknesses, PBMA-b-PIPAAm-coated surfaces are optimized to regulate the adhesion/detachment of cells by temperature changes. Thus, thermoresponsive polymer-coated surfaces are able to harvest contiguous cell sheets with their basal extracellular matrix proteins.
| 本文言語 | English |
|---|---|
| ページ（範囲） | 751-760 |
| ページ数 | 10 |
| ジャーナル | Macromolecular Bioscience |
| 巻 | 12 |
| 号 | 6 |
| DOI | |
| 出版ステータス | Published - 2012 6月 |
ASJC Scopus subject areas
- バイオテクノロジー
- バイオエンジニアリング
- 生体材料
- ポリマーおよびプラスチック
- 材料化学