Thymoma with pemphigus foliaceus

Kei Takeshita; Maki Amano; Takayuki Shimizu; Yoshitaka Oyamada; Tomohiro Abiko; Koichi Kobayashi; Yuko Futei; Masayuki Amagai; Shigeru Kuramochi; Koichiro Asano; Kazuhiro Yamaguchi

doi:10.2169/internalmedicine.39.742

Thymoma with pemphigus foliaceus

Kei Takeshita, Maki Amano, Takayuki Shimizu, Yoshitaka Oyamada, Tomohiro Abiko, Koichi Kobayashi, Yuko Futei, Masayuki Amagai, Shigeru Kuramochi, Koichiro Asano, Kazuhiro Yamaguchi

研究成果: Article › 査読

17 被引用数 (Scopus)

抄録

A 75-year-old Japanese woman was referred to us because of an anterior mediastinal mass. Crusts and shallow erosions developed 10 months earlier on her upper chest, back, and scalp. Pemphigus foliaceus was diagnosed based on histological examination of skin biopsy specimens and positivity for serum anti-desmoglein 1 antibody by enzyme-linked immunosorbent assay. Neurological examination and electromyography ruled out myasthenia gravis. Total thymectomy was performed, and the postoperative pathology studies showed mixed lymphoepithelial thymoma. One year after the resection, the eruption and alopecia improved and the serum anti-desmoglein 1 antibody titer decreased, suggesting a beneficial effect of thymectomy on thymomarelated pemphigus.

本文言語	English
ページ（範囲）	742-747
ページ数	6
ジャーナル	Internal Medicine
巻	39
号	9
DOI	https://doi.org/10.2169/internalmedicine.39.742
出版ステータス	Published - 2000 9月

ASJC Scopus subject areas

内科学

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10.2169/internalmedicine.39.742

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title = "Thymoma with pemphigus foliaceus",

abstract = "A 75-year-old Japanese woman was referred to us because of an anterior mediastinal mass. Crusts and shallow erosions developed 10 months earlier on her upper chest, back, and scalp. Pemphigus foliaceus was diagnosed based on histological examination of skin biopsy specimens and positivity for serum anti-desmoglein 1 antibody by enzyme-linked immunosorbent assay. Neurological examination and electromyography ruled out myasthenia gravis. Total thymectomy was performed, and the postoperative pathology studies showed mixed lymphoepithelial thymoma. One year after the resection, the eruption and alopecia improved and the serum anti-desmoglein 1 antibody titer decreased, suggesting a beneficial effect of thymectomy on thymomarelated pemphigus.",

keywords = "Anti-desmoglein 1 antibody, Thymectomy",

author = "Kei Takeshita and Maki Amano and Takayuki Shimizu and Yoshitaka Oyamada and Tomohiro Abiko and Koichi Kobayashi and Yuko Futei and Masayuki Amagai and Shigeru Kuramochi and Koichiro Asano and Kazuhiro Yamaguchi",

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AU - Takeshita, Kei

AU - Amano, Maki

AU - Shimizu, Takayuki

AU - Oyamada, Yoshitaka

AU - Abiko, Tomohiro

AU - Kobayashi, Koichi

AU - Futei, Yuko

AU - Amagai, Masayuki

AU - Kuramochi, Shigeru

AU - Asano, Koichiro

AU - Yamaguchi, Kazuhiro

PY - 2000/9

Y1 - 2000/9

N2 - A 75-year-old Japanese woman was referred to us because of an anterior mediastinal mass. Crusts and shallow erosions developed 10 months earlier on her upper chest, back, and scalp. Pemphigus foliaceus was diagnosed based on histological examination of skin biopsy specimens and positivity for serum anti-desmoglein 1 antibody by enzyme-linked immunosorbent assay. Neurological examination and electromyography ruled out myasthenia gravis. Total thymectomy was performed, and the postoperative pathology studies showed mixed lymphoepithelial thymoma. One year after the resection, the eruption and alopecia improved and the serum anti-desmoglein 1 antibody titer decreased, suggesting a beneficial effect of thymectomy on thymomarelated pemphigus.

AB - A 75-year-old Japanese woman was referred to us because of an anterior mediastinal mass. Crusts and shallow erosions developed 10 months earlier on her upper chest, back, and scalp. Pemphigus foliaceus was diagnosed based on histological examination of skin biopsy specimens and positivity for serum anti-desmoglein 1 antibody by enzyme-linked immunosorbent assay. Neurological examination and electromyography ruled out myasthenia gravis. Total thymectomy was performed, and the postoperative pathology studies showed mixed lymphoepithelial thymoma. One year after the resection, the eruption and alopecia improved and the serum anti-desmoglein 1 antibody titer decreased, suggesting a beneficial effect of thymectomy on thymomarelated pemphigus.

KW - Anti-desmoglein 1 antibody

KW - Thymectomy

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Thymoma with pemphigus foliaceus

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