TokyoGreen derivatives as specific and practical fluorescent probes for UDP-glucuronosyltransferase (UGT) 1A1

Takuya Terai; Rie Tomiyasu; Tomoe Ota; Tasuku Ueno; Toru Komatsu; Kenjiro Hanaoka; Yasuteru Urano; Tetsuo Nagano

doi:10.1039/c3cc38810g

TokyoGreen derivatives as specific and practical fluorescent probes for UDP-glucuronosyltransferase (UGT) 1A1

Takuya Terai, Rie Tomiyasu, Tomoe Ota, Tasuku Ueno, Toru Komatsu, Kenjiro Hanaoka, Yasuteru Urano, Tetsuo Nagano

研究成果: Article › 査読

20 被引用数 (Scopus)

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TokyoGreen (TG) derivatives were found to be efficient and specific substrates of an important drug-metabolizing enzyme, UDP-glucuronosyltransferase (UGT) 1A1. A rapid, specific, and sensitive assay of the enzyme was achieved simply by monitoring the change in fluorescence intensity. We also designed and developed the first “turn-on” fluorescent probes for UGTs.

本文言語	English
ページ（範囲）	3101-3103
ページ数	3
ジャーナル	Chemical Communications
巻	49
号	30
DOI	https://doi.org/10.1039/c3cc38810g
出版ステータス	Published - 2013 3月 19
外部発表	はい

ASJC Scopus subject areas

触媒
電子材料、光学材料、および磁性材料
セラミックおよび複合材料
化学 (全般)
表面、皮膜および薄膜
金属および合金
材料化学

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AU - Terai, Takuya

AU - Tomiyasu, Rie

AU - Ota, Tomoe

AU - Ueno, Tasuku

AU - Komatsu, Toru

AU - Hanaoka, Kenjiro

AU - Urano, Yasuteru

AU - Nagano, Tetsuo

PY - 2013/3/19

Y1 - 2013/3/19

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AB - TokyoGreen (TG) derivatives were found to be efficient and specific substrates of an important drug-metabolizing enzyme, UDP-glucuronosyltransferase (UGT) 1A1. A rapid, specific, and sensitive assay of the enzyme was achieved simply by monitoring the change in fluorescence intensity. We also designed and developed the first “turn-on” fluorescent probes for UGTs.

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TokyoGreen derivatives as specific and practical fluorescent probes for UDP-glucuronosyltransferase (UGT) 1A1

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