Topical naphazoline in the treatment of myasthenic blepharoptosis

Yuriko Nagane, Kimiaki Utsugisawa, Shigeaki Suzuki, Masayuki Masuda, Yuko Shimizu, Hiroya Utsumi, Shinichiro Uchiyama, Norihiro Suzuki

研究成果: Article査読

14 被引用数 (Scopus)


Introduction. When treating ocular myasthenia gravis (MG), the risk/benefit profile of corticosteroids is unclear, and acetylcholinesterase inhibitors are not very effective. We examined the efficacy of topical naphazoline in the treatment of myasthenic blepharoptosis. Methods. Sixty MG patients with blepharoptosis (32 with ocular symptoms only and 28 with mild generalized symptoms) were enrolled in a multicenter open trial of topical naphazoline. The effects were reported by patients via a questionnaire and were also confirmed for each patient at the clinic. Results. Among 70 eyes of 60 patients, 20 eyes (28.6%) of 17 patients (28.3%) exhibited a marked response (full eye opening), and 24 eyes (34.3%) of 20 patients (33.3%) showed a good response (adequate but incomplete eye opening). Topical naphazoline was evaluated as useful in the treatment of myasthenic blepharoptosis by >70% of the patients. Conclusions. Topical naphazoline was found to be an effective supplementary symptomatic treatment for myasthenic blepharoptosis.

ジャーナルMuscle and Nerve
出版ステータスPublished - 2011 7月

ASJC Scopus subject areas

  • 生理学
  • 臨床神経学
  • 細胞および分子神経科学
  • 生理学(医学)


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