Total synthesis of Antibiotic Нуgromycin A

Noritaka Chida; Masami Ohtsuka; Keiichi Nakazawa; Seiichiro Ogawa

doi:10.1021/jo00009a009

Total synthesis of Antibiotic Нуgromycin A

Noritaka Chida, Masami Ohtsuka, Keiichi Nakazawa, Seiichiro Ogawa

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The first total synthesis of the antibiotic (−)-hygromycin A (1) has been achieved by a coupling reaction of the sugar moiety (2) and the cyclitol moiety (3). Both components were synthesized in homochiral forms starting from D-glucose. This synthesis fully confirmed the unique structure of 1, which is much different from other usual aminocyclitol antibiotics.

本文言語	English
ページ（範囲）	2976-2983
ページ数	8
ジャーナル	Journal of Organic Chemistry
巻	56
号	9
DOI	https://doi.org/10.1021/jo00009a009
出版ステータス	Published - 1991 4月 1

ASJC Scopus subject areas

有機化学

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10.1021/jo00009a009

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AB - The first total synthesis of the antibiotic (−)-hygromycin A (1) has been achieved by a coupling reaction of the sugar moiety (2) and the cyclitol moiety (3). Both components were synthesized in homochiral forms starting from D-glucose. This synthesis fully confirmed the unique structure of 1, which is much different from other usual aminocyclitol antibiotics.

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Total synthesis of Antibiotic Нуgromycin A

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