Total synthesis of merrilactone A

Masayuki Inoue; Takaaki Sato; Masahiro Hirama

doi:10.1021/ja036587+

Total synthesis of merrilactone A

Masayuki Inoue, Takaaki Sato, Masahiro Hirama

研究成果: Article › 査読

110 被引用数 (Scopus)

抄録

Merrilactone A (1) has been shown to possess neurotrophic activity and thus is expected to hold therapeutic potential in the treatment of neurodegeneration diseases. In this paper, we report the total synthesis of (±)-1, employing, as key steps, a novel desymmetrization protocol of meso-diketone to construct the core cis-bicyclo[3.3.0]octyl system of 1 (3 → 2) and a radical cyclization to install the highly congested C9-quaternary carbon (16 → 17).

本文言語	English
ページ（範囲）	10772-10773
ページ数	2
ジャーナル	Journal of the American Chemical Society
巻	125
号	36
DOI	https://doi.org/10.1021/ja036587+
出版ステータス	Published - 2003 9月 10
外部発表	はい

ASJC Scopus subject areas

触媒
化学 (全般)
生化学
コロイド化学および表面化学

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Total synthesis of merrilactone A

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