TY - JOUR
T1 - Total synthesis of nucleoside antibiotics possessing novel N-glycoside structures
AU - Chida, Noritaka
PY - 2008/11
Y1 - 2008/11
N2 - Construction of aryl and heteroaryl N-glycoside structures by way of the palladium-catalyzed Buchwald-Hartwig N-arylation of pyranosylamines with aryl and heteroaryl halide derivatives is described. This methodology was successfully applied to the total synthesis of nucleoside antibiotics, spicamycin and dapiramicin B, possessing novel heteroaryl N-glycosides. Kinetic and thermodynamic analyses of heteroaryl N-glycosides are also reported.
AB - Construction of aryl and heteroaryl N-glycoside structures by way of the palladium-catalyzed Buchwald-Hartwig N-arylation of pyranosylamines with aryl and heteroaryl halide derivatives is described. This methodology was successfully applied to the total synthesis of nucleoside antibiotics, spicamycin and dapiramicin B, possessing novel heteroaryl N-glycosides. Kinetic and thermodynamic analyses of heteroaryl N-glycosides are also reported.
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U2 - 10.5059/yukigoseikyokaishi.66.1105
DO - 10.5059/yukigoseikyokaishi.66.1105
M3 - Article
AN - SCOPUS:60249103759
SN - 0037-9980
VL - 66
SP - 1105
EP - 1115
JO - Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry
JF - Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry
IS - 11
ER -