Total synthesis of (-)-pestalotiopsin A

Ken Ichi Takao; Nobuhiko Hayakawa; Reo Yamada; Taro Yamaguchi; Urara Morita; Soujiro Kawasaki; Kin Ichi Tadano

doi:10.1002/anie.200800253

Total synthesis of (-)-pestalotiopsin A

Ken Ichi Takao, Nobuhiko Hayakawa, Reo Yamada, Taro Yamaguchi, Urara Morita, Soujiro Kawasaki, Kin Ichi Tadano

応用化学科

研究成果: Article › 査読

38 被引用数 (Scopus)

抄録

(Chemical Equation Presented) A big "+": The total synthesis of (-)-pestalotiopsin A has been achieved, thereby establishing the absolute stereochemistry of natural (+)-pestalotiopsin A (see scheme). The synthesis features a [2+2] cycloaddition, an aldol reaction, and an intramolecular Nozaki-Hiyama-Kishi reaction to construct the (E)-cyclononene ring.

本文言語	English
ページ（範囲）	3426-3429
ページ数	4
ジャーナル	Angewandte Chemie - International Edition
巻	47
号	18
DOI	https://doi.org/10.1002/anie.200800253
出版ステータス	Published - 2008 4月 21

ASJC Scopus subject areas

触媒
化学 (全般)

文献へのアクセス

10.1002/anie.200800253

他のファイルとリンク

引用スタイル

@article{5bf9bbef16c44bf69b7b2da027ffd54a,

title = "Total synthesis of (-)-pestalotiopsin A",

abstract = "(Chemical Equation Presented) A big {"}+{"}: The total synthesis of (-)-pestalotiopsin A has been achieved, thereby establishing the absolute stereochemistry of natural (+)-pestalotiopsin A (see scheme). The synthesis features a [2+2] cycloaddition, an aldol reaction, and an intramolecular Nozaki-Hiyama-Kishi reaction to construct the (E)-cyclononene ring.",

keywords = "Chiral auxiliaries, Cyclization, Cycloaddition, Synthesis design",

author = "Takao, {Ken Ichi} and Nobuhiko Hayakawa and Reo Yamada and Taro Yamaguchi and Urara Morita and Soujiro Kawasaki and Tadano, {Kin Ichi}",

year = "2008",

month = apr,

day = "21",

doi = "10.1002/anie.200800253",

language = "English",

volume = "47",

pages = "3426--3429",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "John Wiley and Sons Ltd",

number = "18",

}

TY - JOUR

T1 - Total synthesis of (-)-pestalotiopsin A

AU - Takao, Ken Ichi

AU - Hayakawa, Nobuhiko

AU - Yamada, Reo

AU - Yamaguchi, Taro

AU - Morita, Urara

AU - Kawasaki, Soujiro

AU - Tadano, Kin Ichi

PY - 2008/4/21

Y1 - 2008/4/21

N2 - (Chemical Equation Presented) A big "+": The total synthesis of (-)-pestalotiopsin A has been achieved, thereby establishing the absolute stereochemistry of natural (+)-pestalotiopsin A (see scheme). The synthesis features a [2+2] cycloaddition, an aldol reaction, and an intramolecular Nozaki-Hiyama-Kishi reaction to construct the (E)-cyclononene ring.

AB - (Chemical Equation Presented) A big "+": The total synthesis of (-)-pestalotiopsin A has been achieved, thereby establishing the absolute stereochemistry of natural (+)-pestalotiopsin A (see scheme). The synthesis features a [2+2] cycloaddition, an aldol reaction, and an intramolecular Nozaki-Hiyama-Kishi reaction to construct the (E)-cyclononene ring.

KW - Chiral auxiliaries

KW - Cyclization

KW - Cycloaddition

KW - Synthesis design

UR - http://www.scopus.com/inward/record.url?scp=43849098048&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=43849098048&partnerID=8YFLogxK

U2 - 10.1002/anie.200800253

DO - 10.1002/anie.200800253

M3 - Article

C2 - 18366053

AN - SCOPUS:43849098048

SN - 1433-7851

VL - 47

SP - 3426

EP - 3429

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 18

ER -

Total synthesis of (-)-pestalotiopsin A

抄録

ASJC Scopus subject areas

文献へのアクセス

他のファイルとリンク

フィンガープリント

引用スタイル