@article{eecb8a2b1bb849b5ab0e9e282de8e7fa,
title = "Total synthesis of (+)-spiculoic acid A",
abstract = "The total synthesis of natural (+)-spiculoic acid A, a new cytotoxic marine natural product of polyketide origin, has been accomplished for the first time. The key step of the total synthesis was a stereoselective and high-yielding intramolecular Diels-Alder reaction of a highly functionalized (E,E,E)-2,7,9-dodecanal derivative for the construction of the core tetrahydroindan-2-one skeleton.",
keywords = "(+)-Spiculoic acid A, Cytotoxicity, Intramolecular Diels-Alder reaction, Marine natural product, Suzuki-Miyaura coupling, Total synthesis",
author = "Daisuke Matsumura and Takumi Toda and Takashi Hayamizu and Kiyoto Sawamura and Takao, {Ken ichi} and Tadano, {Kin ichi}",
note = "Funding Information: This work was supported by Grants-in-Aid for Scientific Research on Priority Areas (A) {\textquoteleft}Creation of Biologically Functional Molecules (18032069){\textquoteright} from the Ministry of Education, Culture, Sports, Science, and Technology, Japan. ",
year = "2009",
month = jul,
day = "1",
doi = "10.1016/j.tetlet.2009.02.101",
language = "English",
volume = "50",
pages = "3356--3358",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier Limited",
number = "26",
}
