Translational medicine of the glutamate AMPA receptor

By Tomoyuki MIYAZAKI, Hiroki ABE, Hiroyuki UCHIDA, Takuya TAKAHASHI

研究成果: Article査読

6 被引用数 (Scopus)


Psychiatric and neurological disorders severely hamper patient’s quality of life. Despite their high unmet needs, the development of diagnostics and therapeutics has only made slow progress. This is due to limited evidence on the biological basis of these disorders in humans. Synapses are essential structural units of neurotransmission, and neuropsychiatric disorders are considered as “synapse diseases”. Thus, a translational approach with synaptic physiology is crucial to tackle these disorders. Among a variety of synapses, excitatory glutamatergic synapses play central roles in neuronal functions. The glutamate,-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPAR) is a principal component of glutamatergic neurotransmission; therefore, it is considered to be a promising translational target. Here, we review the limitations of current diagnostics and therapeutics of neuropsychiatric disorders and advocate the urgent need for the promotion of translational medicine based on the synaptic physiology of AMPAR. Furthermore, we introduce our recent translational approach to these disorders by targeting at AMPARs.

ジャーナルProceedings of the Japan Academy Series B: Physical and Biological Sciences
出版ステータスPublished - 2021

ASJC Scopus subject areas

  • 農業および生物科学一般
  • 物理学および天文学一般


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