DBA/2 mice implanted i.p. with an aclarubicin (ACR)–resistant subline of L5178Y cells survived 4- to 5-fold longer than those with the parental cells; and animals with the Adriamycin- or bleomycin–resistant subline displayed an intermediate survival period. The i.p. treatment of mice with cyclophosphamide markedly enhanced i.p. growth of the ACR–resistant cells, suggesting that A certain host defense mechanism participates in the lower transplantability. In vitro, the ACR–resistant subline showed much higher sensitivity to natural killer cells. The i.p. pretreatment with anti-asialo-GM1 antibody markedly reduced the mean survival period of mice implanted i.p. with the ACR–resistant cells, suggesting that natural killer cells play an important role in the defense against transplantation of the ACR–resistant cells. copyright.
|Published - 1986 11月 1
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