@article{54056d78c8e0478fb9f2ba8c7cfef056,
title = "Treatment with a Gamma-Secretase Inhibitor Promotes Functional Recovery in Human iPSC- Derived Transplants for Chronic Spinal Cord Injury",
abstract = "In this article, Okano and colleagues show that the GSI-treated hiPSC-NS/PCs caused significantly enhanced axonal regrowth, remyelination, inhibitory synapse formation with the host neural circuitry, and reticulo spinal tract fiber formation. These favorable outcomes contributed to motor function improvement. Therefore, treating cells with GSI provides a beneficial effect after transplantation, even in the chronic phase following SCI.",
keywords = "Notch signaling, axonal regrowth, chronic spinal cord injury, gamma-secretase inhibitor, iPS cell, motor function, p38 MAPK, regenerative medicine, transplantation",
author = "Toshiki Okubo and Narihito Nagoshi and Jun Kohyama and Osahiko Tsuji and Munehisa Shinozaki and Shinsuke Shibata and Yoshitaka Kase and Morio Matsumoto and Masaya Nakamura and Hideyuki Okano",
note = "Funding Information: We appreciate the assistance of Drs. K. Kojima, S. Ito, Y Tanimoto, and Y Hoshino, who are all members of the Spinal Cord Research Team in the Department of Orthopedic Surgery, Keio University School of Medicine, Tokyo, Japan. We thank Prof. Shinya Yamanaka for the human iPSC clones (201B7 and 414C2). We also thank Ms. T. Harada, Ms. K. Yasutake, and Ms. M. Akizawa for their assistance with the experiments and animal care. This work was supported by the Research Center Network for Realization of Regenerative Medicine of the Japan Agency for Medical Research and Development (AMED) (grant no. 15bm0204001h0003 to H.O. and M.N.), and by a medical research grant related to traffic accidents from the General Insurance Association of Japan. H.O. is a compensated scientific consultant of San Bio, and K Pharma, and M.N. is a compensated scientific consultant of K Pharma. Publisher Copyright: {\textcopyright} 2018 The Authors",
year = "2018",
month = dec,
day = "11",
doi = "10.1016/j.stemcr.2018.10.022",
language = "English",
volume = "11",
pages = "1416--1432",
journal = "Stem cell reports",
issn = "2213-6711",
publisher = "Cell Press",
number = "6",
}