TY - JOUR
T1 - Trypanocidal constituents from Michelia alba
AU - Asaruddin, Mohd Razip
AU - Honda, Gisho
AU - Tsubouchi, Akiko
AU - Nakajima-Shimada, Junko
AU - Aoki, Takashi
AU - Kiuchi, Fumiyuki
PY - 2003/4/1
Y1 - 2003/4/1
N2 - The AcOEt extract of the bark of M. alba D.C. (Magnoliaceae) exhibited killing activity against Trypanosoma cruzi. Column chromatographic separation of the extract guided by trypanocidal activity afforded eight trypanocidal constituents; caryophyllene oxide (1), costunolide (2), dihydrocostunolide (3), parthenolide (4), dihydroparthenolide (5), 11, 13-dehydrolanuginolide (6) santamarine (7) and a new monoterpene (8). The structure of monoterpene 8 was determined to be dehydrolinalool oxide on the basis of spectroscopic analyses. The minimum lethal concentrations of these compounds against epimastigotes of T. cruzi were 61 μM, 7 μM, 27 μM, 0.04 μM, 0.78 μM, 0.16 μM, 25 μM, and 5 μM, respectively.
AB - The AcOEt extract of the bark of M. alba D.C. (Magnoliaceae) exhibited killing activity against Trypanosoma cruzi. Column chromatographic separation of the extract guided by trypanocidal activity afforded eight trypanocidal constituents; caryophyllene oxide (1), costunolide (2), dihydrocostunolide (3), parthenolide (4), dihydroparthenolide (5), 11, 13-dehydrolanuginolide (6) santamarine (7) and a new monoterpene (8). The structure of monoterpene 8 was determined to be dehydrolinalool oxide on the basis of spectroscopic analyses. The minimum lethal concentrations of these compounds against epimastigotes of T. cruzi were 61 μM, 7 μM, 27 μM, 0.04 μM, 0.78 μM, 0.16 μM, 25 μM, and 5 μM, respectively.
KW - Magnoliaceae
KW - Michelia alba
KW - Monoterpene
KW - Sesquiterpene lactone
KW - Trypanosoma cruzi
UR - http://www.scopus.com/inward/record.url?scp=0038669081&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0038669081&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0038669081
SN - 1340-3443
VL - 57
SP - 61
EP - 63
JO - Natural Medicines
JF - Natural Medicines
IS - 2
ER -