TY - JOUR
T1 - Trypanocidal constituents of Dracocephalum komarovi
AU - Uchiyama, Nahoko
AU - Kiuchi, Fumiyuki
AU - Ito, Michiho
AU - Honda, Gisho
AU - Takeda, Yoshio
AU - Khodzhimatov, Olimjon K.
AU - Ashurmetov, Ozodbek A.
N1 - Funding Information:
This work was supported in part by a Grant-in-Aid for Scientific Research (No. 12576027) from the Japan Society for the Promotion of Science.
PY - 2006/5/1
Y1 - 2006/5/1
N2 - Trypanocidal constituents of Dracocephalum komarovi were investigated. Under guidance of the in vitro trypanocidal activity against epimastigotes of Trypanosoma cruzi, the causative agent of Chagas' disease, two new diterpenes, dracocequinones A (1) and B (2), and two known triterpene acids, ursonic acid and ursolic acid, were isolated as trypanocidal constituents, in addition to previously reported diterpenes, cyclocoulterone (4), komaroviquinone (5), dracocephalone A (6) and komarovispirone (7). Furthermore a new diterpene, komarovinone A (3), was isolated, together with four known terpenes. Among these compounds, komaroviquinone (5) showed the most potent activity with minimum lethal concentration of 0.4 μM. Structure elucidation of the new diterpenes 1-3 was described.
AB - Trypanocidal constituents of Dracocephalum komarovi were investigated. Under guidance of the in vitro trypanocidal activity against epimastigotes of Trypanosoma cruzi, the causative agent of Chagas' disease, two new diterpenes, dracocequinones A (1) and B (2), and two known triterpene acids, ursonic acid and ursolic acid, were isolated as trypanocidal constituents, in addition to previously reported diterpenes, cyclocoulterone (4), komaroviquinone (5), dracocephalone A (6) and komarovispirone (7). Furthermore a new diterpene, komarovinone A (3), was isolated, together with four known terpenes. Among these compounds, komaroviquinone (5) showed the most potent activity with minimum lethal concentration of 0.4 μM. Structure elucidation of the new diterpenes 1-3 was described.
KW - Diterpene
KW - Dracocephalum komarovi
KW - Trypanocidal activity
KW - Trypanosoma cruzi
UR - http://www.scopus.com/inward/record.url?scp=33646099184&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33646099184&partnerID=8YFLogxK
U2 - 10.1016/j.tet.2006.02.067
DO - 10.1016/j.tet.2006.02.067
M3 - Article
AN - SCOPUS:33646099184
SN - 0040-4020
VL - 62
SP - 4355
EP - 4359
JO - Tetrahedron
JF - Tetrahedron
IS - 18
ER -
