@article{bc0c91ccaff04b9fa85c43d2ca1fe5cc,
title = "Tumor suppression by stromal TIMPs",
abstract = "The tumor stroma has the capacity to drive cancer progression, although the mechanisms governing these effects are incompletely understood. Recently, we reported that deletion of tissue inhibitor of metalloproteinases (Timps) in fibroblasts unleashes the function of cancer-associated fibroblasts and identifies a novel mode of stromal–tumor communication that activates key oncogenic pathways invoving Notch and ras homolog gene family, member A (RhoA) via stromal exosomes.",
keywords = "ADAM10, CAF, Notch, RhoA, TIMP, complete Timp deficiency, exosomes",
author = "Masayuki Shimoda and Jackson, {Hartland W.} and Rama Khokha",
note = "Funding Information: This work is supported by funding from the Canadian Institutes of Health Research and Ontario Institute of Cancer Research to the Khokha lab. Publisher Copyright: {\textcopyright} 2015, {\textcopyright} 2015 The Author(s). Published with license by Taylor & Francis Group, LLC. {\textcopyright} 2015, {\textcopyright} Masayuki Shimoda, Hartland W. Jackson, and Rama Khokha.",
year = "2016",
month = may,
day = "3",
doi = "10.4161/23723556.2014.975082",
language = "English",
volume = "3",
journal = "Molecular and Cellular Oncology",
issn = "2372-3556",
publisher = "Taylor and Francis Ltd.",
number = "3",
}
