TY - JOUR
T1 - Two cases of "fulminant" type 1 diabetes suggesting involvement of autoimmunity
AU - Nakagawa A, Yoshinori
AU - Shimada, Akira
AU - Oikawa, Yoichi
AU - Irie, Jun Ichiro
AU - Shigihara, Toshkatsu
AU - Tsumura, Kazuhiro
AU - Narumi, Shosaku
AU - Saruta, Takao
PY - 2003
Y1 - 2003
N2 - Recently, a novel subtype of type 1 diabetes, so-called fulminant type 1 diabetes, has been proposed. One of the characteristics of this subtype is the absence of detectable "islet-associated" autoantibody, so it was originally proposed as being "nonautoimmune-mediated"; however, it has not yet been concluded whether autoimmunity is involved. We have previously shown that serum interferon-inducible protein-10 and glutamic acid decarboxylase-reactive CD4+ interferon-γ-producing cells in the peripheral blood are good markers for T cell-mediated autoimmunity in type 1 diabetes. Here, we report two cases of fulminant type 1 diabetes in which these markers were detected and in which the involvement of islet-associated autoimmunity is suggested.
AB - Recently, a novel subtype of type 1 diabetes, so-called fulminant type 1 diabetes, has been proposed. One of the characteristics of this subtype is the absence of detectable "islet-associated" autoantibody, so it was originally proposed as being "nonautoimmune-mediated"; however, it has not yet been concluded whether autoimmunity is involved. We have previously shown that serum interferon-inducible protein-10 and glutamic acid decarboxylase-reactive CD4+ interferon-γ-producing cells in the peripheral blood are good markers for T cell-mediated autoimmunity in type 1 diabetes. Here, we report two cases of fulminant type 1 diabetes in which these markers were detected and in which the involvement of islet-associated autoimmunity is suggested.
KW - Fulminant type 1 diabetes mellitus
KW - Glutamic acid decarboxylase (GAD)
KW - Interferon-inducible protein-10 (IP-10)
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U2 - 10.1196/annals.1288.059
DO - 10.1196/annals.1288.059
M3 - Article
C2 - 14679092
AN - SCOPUS:1942538601
SN - 0077-8923
VL - 1005
SP - 359
EP - 361
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
ER -
