Two cases of "fulminant" type 1 diabetes suggesting involvement of autoimmunity

Yoshinori Nakagawa A, Akira Shimada, Yoichi Oikawa, Jun Ichiro Irie, Toshkatsu Shigihara, Kazuhiro Tsumura, Shosaku Narumi, Takao Saruta

研究成果: Article査読

16 被引用数 (Scopus)


Recently, a novel subtype of type 1 diabetes, so-called fulminant type 1 diabetes, has been proposed. One of the characteristics of this subtype is the absence of detectable "islet-associated" autoantibody, so it was originally proposed as being "nonautoimmune-mediated"; however, it has not yet been concluded whether autoimmunity is involved. We have previously shown that serum interferon-inducible protein-10 and glutamic acid decarboxylase-reactive CD4+ interferon-γ-producing cells in the peripheral blood are good markers for T cell-mediated autoimmunity in type 1 diabetes. Here, we report two cases of fulminant type 1 diabetes in which these markers were detected and in which the involvement of islet-associated autoimmunity is suggested.

ジャーナルAnnals of the New York Academy of Sciences
出版ステータスPublished - 2003

ASJC Scopus subject areas

  • 神経科学(全般)
  • 生化学、遺伝学、分子生物学(全般)
  • 科学史および科学哲学


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