TY - JOUR
T1 - Type I Inteferon Gene Induction by the Interferon Regulatory Factor Family of Transcription Factors
AU - Honda, Kenya
AU - Takaoka, Akinori
AU - Taniguchi, Tadatsugu
N1 - Funding Information:
We thank J. Vilcek, E. Barsoumian, Y. Ohba, H. Negishi, and H. Yanai for valuable discussion and advice. This work was supported by Kakenhi (Grant-in-Aid for Scientific Research) on Priority Areas “Integrative Research Toward the Conquest of Cancer” from the Ministry of Education, Culture, Sports, Science, and Technology of Japan and the Uehara Memorial Foundation.
PY - 2006/9
Y1 - 2006/9
N2 - Induction of type I interferons (IFNs) by viruses and other pathogens is crucial for innate immunity, and it is mediated by the activation of pattern-recognition receptors, such as Toll-like receptors and cytosolic receptors such as RIG-I and MDA5. The type I IFN induction is primarily controlled at the gene transcriptional level, wherein a family of transcription factors, interferon regulatory factors (IRFs), plays central roles. Here, we summarize the recent studies on IRFs, providing a paradigm of how genes are ingeniously regulated during immune responses. We also consider some evolutional aspects on the IFN-IRF system.
AB - Induction of type I interferons (IFNs) by viruses and other pathogens is crucial for innate immunity, and it is mediated by the activation of pattern-recognition receptors, such as Toll-like receptors and cytosolic receptors such as RIG-I and MDA5. The type I IFN induction is primarily controlled at the gene transcriptional level, wherein a family of transcription factors, interferon regulatory factors (IRFs), plays central roles. Here, we summarize the recent studies on IRFs, providing a paradigm of how genes are ingeniously regulated during immune responses. We also consider some evolutional aspects on the IFN-IRF system.
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U2 - 10.1016/j.immuni.2006.08.009
DO - 10.1016/j.immuni.2006.08.009
M3 - Review article
C2 - 16979567
AN - SCOPUS:33748475531
SN - 1074-7613
VL - 25
SP - 349
EP - 360
JO - Immunity
JF - Immunity
IS - 3
ER -
