Ulbactins F and G, Polycyclic Thiazoline Derivatives with Tumor Cell Migration Inhibitory Activity from Brevibacillus sp.

Yasuhiro Igarashi; Daisuke Asano; Masashi Sawamura; Yasuko In; Toshimasa Ishida; Masaya Imoto

doi:10.1021/acs.orglett.6b00531

Ulbactins F and G, Polycyclic Thiazoline Derivatives with Tumor Cell Migration Inhibitory Activity from Brevibacillus sp.

Yasuhiro Igarashi, Daisuke Asano, Masashi Sawamura, Yasuko In, Toshimasa Ishida, Masaya Imoto

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研究成果: Article › 査読

27 被引用数 (Scopus)

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Two new structurally unique compounds bearing a nitrogen- and sulfur-containing tricyclic ring system, ulbactin F (1) and its diastereomeric isomer ulbactin G (2), were isolated from the culture extract of a sponge-derived Brevibacillus sp. The structures and absolute configurations of 1 and 2 were determined by NMR analysis and X-ray crystallographic analysis. These compounds inhibit the migration of tumor cells in the submicromolar to micromolar range.

本文言語	English
ページ（範囲）	1658-1661
ページ数	4
ジャーナル	Organic Letters
巻	18
号	7
DOI	https://doi.org/10.1021/acs.orglett.6b00531
出版ステータス	Published - 2016 4月 15

ASJC Scopus subject areas

生化学
物理化学および理論化学
有機化学

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10.1021/acs.orglett.6b00531

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abstract = "Two new structurally unique compounds bearing a nitrogen- and sulfur-containing tricyclic ring system, ulbactin F (1) and its diastereomeric isomer ulbactin G (2), were isolated from the culture extract of a sponge-derived Brevibacillus sp. The structures and absolute configurations of 1 and 2 were determined by NMR analysis and X-ray crystallographic analysis. These compounds inhibit the migration of tumor cells in the submicromolar to micromolar range.",

author = "Yasuhiro Igarashi and Daisuke Asano and Masashi Sawamura and Yasuko In and Toshimasa Ishida and Masaya Imoto",

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AU - Igarashi, Yasuhiro

AU - Asano, Daisuke

AU - Sawamura, Masashi

AU - In, Yasuko

AU - Ishida, Toshimasa

AU - Imoto, Masaya

PY - 2016/4/15

Y1 - 2016/4/15

N2 - Two new structurally unique compounds bearing a nitrogen- and sulfur-containing tricyclic ring system, ulbactin F (1) and its diastereomeric isomer ulbactin G (2), were isolated from the culture extract of a sponge-derived Brevibacillus sp. The structures and absolute configurations of 1 and 2 were determined by NMR analysis and X-ray crystallographic analysis. These compounds inhibit the migration of tumor cells in the submicromolar to micromolar range.

AB - Two new structurally unique compounds bearing a nitrogen- and sulfur-containing tricyclic ring system, ulbactin F (1) and its diastereomeric isomer ulbactin G (2), were isolated from the culture extract of a sponge-derived Brevibacillus sp. The structures and absolute configurations of 1 and 2 were determined by NMR analysis and X-ray crystallographic analysis. These compounds inhibit the migration of tumor cells in the submicromolar to micromolar range.

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JO - Organic Letters

JF - Organic Letters

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Ulbactins F and G, Polycyclic Thiazoline Derivatives with Tumor Cell Migration Inhibitory Activity from Brevibacillus sp.

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