Understanding human myeloid dendritic cell subsets for the rational design of novel vaccines

Eynav Klechevsky, Maochang Liu, Rimpei Morita, Romain Banchereau, Luann Thompson-Snipes, A. Karolina Palucka, Hideki Ueno, Jacques Banchereau

研究成果: Article査読

64 被引用数 (Scopus)


Dendritic cells (DCs) orchestrate a repertoire of immune responses that endows resistance to infection and tolerance to self. Understanding the principles by which DCs control immunity and tolerance has provided a rich basis for studying and improving clinical outcome of human disease treatment. Several features contribute to the complexity of the DC system. Among these, plasticity and existence of subsets are prominent determinants to the quality of the elicited immune responses. Indeed, different DC subsets are distributed in peripheral tissues and the blood and display different microbial receptors, surface molecules and cytokine expression, all of which influence the immunologic outcome. The biologic raison d'être for separate DC subsets has been the focus of many studies including our own and is being reviewed with an emphasis on human skin DCs.

ジャーナルHuman Immunology
出版ステータスPublished - 2009 5月

ASJC Scopus subject areas

  • 免疫アレルギー学
  • 免疫学


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