@inproceedings{e1aef92770274306a414fbaaefdebcec,
title = "UNIDIRECTIONAL ANALYSIS OF CARDIAC PROPAGATION VELOCITY BY HUMAN IPSC-DERIVED CARDIAC CORE-SHELL MICROFIBER",
abstract = "We propose a simple and quantitative assessment of cardiac maturation by calcium propagation velocity. A microfiber-shaped cardiac tissue enables the uniform orientation of cardiomyocyte along the fiber direction, allowing the easy calculation of propagation velocities by one-way-transmission of signals over a long distance. We evaluated the maturation of our microfiber tissues by electrical stimulation and detected 26\% increase in the propagation velocity comparing to the immature tissue. Our system of maturity assessment would contribute to the construction of matured cardiac model as a platform for elucidating the pathology of cardiac diseases and drug effects.",
keywords = "Calcium Imaging, Cardiac Tissue, iPSCs, Microfiber, Propagation Velocity, Tissue Engineering",
author = "Akari Masuda and Shun Itai and Yuta Kurashina and Shugo Tohyama and Hiroaki Onoe",
note = "Publisher Copyright: {\textcopyright} 2022 MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences. All rights reserved.; 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2022 ; Conference date: 23-10-2022 Through 27-10-2022",
year = "2022",
language = "English",
series = "MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences",
publisher = "Chemical and Biological Microsystems Society",
pages = "362--363",
booktitle = "MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences",
}