Urumamide, a novel chymotrypsin inhibitor with a β-amino acid from a marine cyanobacterium Okeania sp.

Yuki Kanamori; Arihiro Iwasaki; Shinpei Sumimoto; Kiyotake Suenaga

doi:10.1016/j.tetlet.2016.08.012

Urumamide, a novel chymotrypsin inhibitor with a β-amino acid from a marine cyanobacterium Okeania sp.

Yuki Kanamori, Arihiro Iwasaki, Shinpei Sumimoto, Kiyotake Suenaga

化学科

研究成果: Article › 査読

10 被引用数 (Scopus)

抄録

Urumamide, a novel cyclic depsipeptide that contains a β-amino acid, was isolated from a marine cyanobacterium Okeania sp. Its gross structure was determined by spectroscopic analyses, and the absolute configuration was established based on Marfey's analyses and chiral HPLC analyses of hydrolysis products. Biologically, urumamide inhibited the growth of human cancer cells. In addition, urumamide inhibited chymotrypsin.

本文言語	English
ページ（範囲）	4213-4216
ページ数	4
ジャーナル	Tetrahedron Letters
巻	57
号	37
DOI	https://doi.org/10.1016/j.tetlet.2016.08.012
出版ステータス	Published - 2016

ASJC Scopus subject areas

生化学
創薬
有機化学

UN SDG

この成果は、次の持続可能な開発目標に貢献しています

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10.1016/j.tetlet.2016.08.012

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title = "Urumamide, a novel chymotrypsin inhibitor with a β-amino acid from a marine cyanobacterium Okeania sp.",

abstract = "Urumamide, a novel cyclic depsipeptide that contains a β-amino acid, was isolated from a marine cyanobacterium Okeania sp. Its gross structure was determined by spectroscopic analyses, and the absolute configuration was established based on Marfey's analyses and chiral HPLC analyses of hydrolysis products. Biologically, urumamide inhibited the growth of human cancer cells. In addition, urumamide inhibited chymotrypsin.",

keywords = "Depsipeptide, Marine cyanobacteria, Okeania, Urumamide, β-Amino acid",

author = "Yuki Kanamori and Arihiro Iwasaki and Shinpei Sumimoto and Kiyotake Suenaga",

note = "Funding Information: This work was supported by JSPS KAKENHI Grant Number 16H03285 . Publisher Copyright: {\textcopyright} 2016",

year = "2016",

doi = "10.1016/j.tetlet.2016.08.012",

language = "English",

volume = "57",

pages = "4213--4216",

journal = "Tetrahedron Letters",

issn = "0040-4039",

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TY - JOUR

T1 - Urumamide, a novel chymotrypsin inhibitor with a β-amino acid from a marine cyanobacterium Okeania sp.

AU - Kanamori, Yuki

AU - Iwasaki, Arihiro

AU - Sumimoto, Shinpei

AU - Suenaga, Kiyotake

PY - 2016

Y1 - 2016

N2 - Urumamide, a novel cyclic depsipeptide that contains a β-amino acid, was isolated from a marine cyanobacterium Okeania sp. Its gross structure was determined by spectroscopic analyses, and the absolute configuration was established based on Marfey's analyses and chiral HPLC analyses of hydrolysis products. Biologically, urumamide inhibited the growth of human cancer cells. In addition, urumamide inhibited chymotrypsin.

AB - Urumamide, a novel cyclic depsipeptide that contains a β-amino acid, was isolated from a marine cyanobacterium Okeania sp. Its gross structure was determined by spectroscopic analyses, and the absolute configuration was established based on Marfey's analyses and chiral HPLC analyses of hydrolysis products. Biologically, urumamide inhibited the growth of human cancer cells. In addition, urumamide inhibited chymotrypsin.

KW - Depsipeptide

KW - Marine cyanobacteria

KW - Okeania

KW - Urumamide

KW - β-Amino acid

UR - http://www.scopus.com/inward/record.url?scp=84983089397&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84983089397&partnerID=8YFLogxK

U2 - 10.1016/j.tetlet.2016.08.012

DO - 10.1016/j.tetlet.2016.08.012

M3 - Article

AN - SCOPUS:84983089397

SN - 0040-4039

VL - 57

SP - 4213

EP - 4216

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 37

ER -

Urumamide, a novel chymotrypsin inhibitor with a β-amino acid from a marine cyanobacterium Okeania sp.

抄録

ASJC Scopus subject areas

UN SDG

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