Usefulness of circulating amino acid profile and Fischer ratio to predict severity of pulmonary hypertension

Ryoji Yanagisawa, Masaharu Kataoka, Takumi Inami, Yuichi Momose, Takashi Kawakami, Makoto Takei, Mai Kimura, Sarasa Isobe, Minoru Yamakado, Keiichi Fukuda, Hideaki Yoshino, Motoaki Sano, Toru Satoh

研究成果: Article査読

14 被引用数 (Scopus)


Plasma amino acid concentrations (aminogram) show distinct patterns under various pathologic conditions. However, the plasma aminogram pattern in patients with pulmonary hypertension (PH) has not been elucidated. We sought to examine whether an aminogram could be predictive of clinical severity in patients with PH. We attained fasting plasma aminograms for 140 patients with PH and then compared the patient plasma amino acid levels with those of age- and gender-matched healthy control subjects. Aminograms revealed that the plasma concentrations of many amino acids were significantly different between patients with PH and healthy control subjects. We focused on the Fischer ratio (branched-chain amino acids/aromatic amino acids) as an integrated parameter. In all enrolled patients, Fischer ratio was negatively correlated with New York Heart Association functional class (ρ = -0.37, p <0.001), plasma B-type natriuretic peptide (ρ = -0.35, p <0.001), and pulmonary vascular resistance (ρ = -0.27, p = 0.002) and positively correlated with venous oxygen saturation (ρ = 0.27, p = 0.002) and 6-minute walk distance (ρ = 0.23, p = 0.016). Time course changes in Fischer ratio and in cardiac output were significantly correlated (ρ = 0.39, p = 0.024). The aminogram is changed in patients with PH, and in these patients, Fischer ratio decreases in proportion to the clinical severity of PH.

ジャーナルAmerican Journal of Cardiology
出版ステータスPublished - 2015 3月 15

ASJC Scopus subject areas

  • 循環器および心血管医学


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