Vacuolar-type H+-ATPase inhibitory activity of synthetic analogues of the concanamycins: Is the hydrogen bond network involving the lactone carbonyl, the hemiacetal hydroxy group, and the C-19 hydroxy group essential for the biological activity of the concanamycins?

Yuya Yoshimoto; Takaaki Jyojima; Tsuyoshi Arita; Minoru Ueda; Masaya Imoto; Shuichi Matsumura; Kazunobu Toshima

doi:10.1016/S0960-894X(02)00806-5

Vacuolar-type H⁺-ATPase inhibitory activity of synthetic analogues of the concanamycins: Is the hydrogen bond network involving the lactone carbonyl, the hemiacetal hydroxy group, and the C-19 hydroxy group essential for the biological activity of the concanamycins?

Yuya Yoshimoto, Takaaki Jyojima, Tsuyoshi Arita, Minoru Ueda, Masaya Imoto, Shuichi Matsumura, Kazunobu Toshima

応用化学科

研究成果: Article › 査読

10 被引用数 (Scopus)

抄録

Synthetic analogue of the concanamycins, which lacks the hydrogen bond network existing in the concanamycin structure, retains vacuolar-type H⁺-ATPase (V-ATPase) inhibitory activity and induces apoptosis to cancer cells that overexpressing epidermal growth factor receptors (EGFR).

本文言語	English
ページ（範囲）	3525-3528
ページ数	4
ジャーナル	Bioorganic and Medicinal Chemistry Letters
巻	12
号	24
DOI	https://doi.org/10.1016/S0960-894X(02)00806-5
出版ステータス	Published - 2002 12月

ASJC Scopus subject areas

生化学
分子医療
分子生物学
薬科学
創薬
臨床生化学
有機化学

UN SDG

この成果は、次の持続可能な開発目標に貢献しています

文献へのアクセス

10.1016/S0960-894X(02)00806-5

他のファイルとリンク

フィンガープリント

「Vacuolar-type H⁺-ATPase inhibitory activity of synthetic analogues of the concanamycins: Is the hydrogen bond network involving the lactone carbonyl, the hemiacetal hydroxy group, and the C-19 hydroxy group essential for the biological activity of the concanamycins?」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル

Yoshimoto, Y., Jyojima, T., Arita, T., Ueda, M., Imoto, M., Matsumura, S., & Toshima, K. (2002). Vacuolar-type H⁺-ATPase inhibitory activity of synthetic analogues of the concanamycins: Is the hydrogen bond network involving the lactone carbonyl, the hemiacetal hydroxy group, and the C-19 hydroxy group essential for the biological activity of the concanamycins? Bioorganic and Medicinal Chemistry Letters, 12(24), 3525-3528. https://doi.org/10.1016/S0960-894X(02)00806-5

Vacuolar-type H⁺-ATPase inhibitory activity of synthetic analogues of the concanamycins: Is the hydrogen bond network involving the lactone carbonyl, the hemiacetal hydroxy group, and the C-19 hydroxy group essential for the biological activity of the concanamycins? / Yoshimoto, Yuya; Jyojima, Takaaki; Arita, Tsuyoshi その他.
In: Bioorganic and Medicinal Chemistry Letters, Vol. 12, No. 24, 12.2002, p. 3525-3528.

研究成果: Article › 査読

Yoshimoto, Y, Jyojima, T, Arita, T, Ueda, M, Imoto, M, Matsumura, S & Toshima, K 2002, 'Vacuolar-type H⁺-ATPase inhibitory activity of synthetic analogues of the concanamycins: Is the hydrogen bond network involving the lactone carbonyl, the hemiacetal hydroxy group, and the C-19 hydroxy group essential for the biological activity of the concanamycins?', Bioorganic and Medicinal Chemistry Letters, vol. 12, no. 24, pp. 3525-3528. https://doi.org/10.1016/S0960-894X(02)00806-5

Yoshimoto Y, Jyojima T, Arita T, Ueda M, Imoto M, Matsumura S その他. Vacuolar-type H⁺-ATPase inhibitory activity of synthetic analogues of the concanamycins: Is the hydrogen bond network involving the lactone carbonyl, the hemiacetal hydroxy group, and the C-19 hydroxy group essential for the biological activity of the concanamycins? Bioorganic and Medicinal Chemistry Letters. 2002 12月;12(24):3525-3528. doi: 10.1016/S0960-894X(02)00806-5

Yoshimoto, Yuya ; Jyojima, Takaaki ; Arita, Tsuyoshi その他. / Vacuolar-type H⁺-ATPase inhibitory activity of synthetic analogues of the concanamycins : Is the hydrogen bond network involving the lactone carbonyl, the hemiacetal hydroxy group, and the C-19 hydroxy group essential for the biological activity of the concanamycins?. In: Bioorganic and Medicinal Chemistry Letters. 2002 ; Vol. 12, No. 24. pp. 3525-3528.

@article{3ac2b84fb3304875bbcd15fa3272ce67,

title = "Vacuolar-type H+-ATPase inhibitory activity of synthetic analogues of the concanamycins: Is the hydrogen bond network involving the lactone carbonyl, the hemiacetal hydroxy group, and the C-19 hydroxy group essential for the biological activity of the concanamycins?",

abstract = "Synthetic analogue of the concanamycins, which lacks the hydrogen bond network existing in the concanamycin structure, retains vacuolar-type H+-ATPase (V-ATPase) inhibitory activity and induces apoptosis to cancer cells that overexpressing epidermal growth factor receptors (EGFR).",

author = "Yuya Yoshimoto and Takaaki Jyojima and Tsuyoshi Arita and Minoru Ueda and Masaya Imoto and Shuichi Matsumura and Kazunobu Toshima",

year = "2002",

month = dec,

doi = "10.1016/S0960-894X(02)00806-5",

language = "English",

volume = "12",

pages = "3525--3528",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Limited",

number = "24",

}

TY - JOUR

T1 - Vacuolar-type H+-ATPase inhibitory activity of synthetic analogues of the concanamycins

T2 - Is the hydrogen bond network involving the lactone carbonyl, the hemiacetal hydroxy group, and the C-19 hydroxy group essential for the biological activity of the concanamycins?

AU - Yoshimoto, Yuya

AU - Jyojima, Takaaki

AU - Arita, Tsuyoshi

AU - Ueda, Minoru

AU - Imoto, Masaya

AU - Matsumura, Shuichi

AU - Toshima, Kazunobu

PY - 2002/12

Y1 - 2002/12

N2 - Synthetic analogue of the concanamycins, which lacks the hydrogen bond network existing in the concanamycin structure, retains vacuolar-type H+-ATPase (V-ATPase) inhibitory activity and induces apoptosis to cancer cells that overexpressing epidermal growth factor receptors (EGFR).

AB - Synthetic analogue of the concanamycins, which lacks the hydrogen bond network existing in the concanamycin structure, retains vacuolar-type H+-ATPase (V-ATPase) inhibitory activity and induces apoptosis to cancer cells that overexpressing epidermal growth factor receptors (EGFR).

UR - http://www.scopus.com/inward/record.url?scp=0036889972&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036889972&partnerID=8YFLogxK

U2 - 10.1016/S0960-894X(02)00806-5

DO - 10.1016/S0960-894X(02)00806-5

M3 - Article

C2 - 12443768

AN - SCOPUS:0036889972

SN - 0960-894X

VL - 12

SP - 3525

EP - 3528

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 24

ER -