Validity of prognostic grading indices for brain metastasis patients undergoing repeat radiosurgery

Masaaki Yamamoto, Takuya Kawabe, Yoshinori Higuchi, Yasunori Sato, Tadashi Nariai, Shinya Watanabe, Bierta E. Barfod, Hidetoshi Kasuya

研究成果: Review article査読

18 被引用数 (Scopus)


Objectives We tested the validity of 5 prognostic indices, Recursive Partitioning Analysis (RPA), Score Index for Radiosurgery (SIR), Basic Score for Brain Metastases (BSBM), Graded Prognostic Assessment (GPA), and Modified-RPA, for patients who underwent repeat stereotactic radiosurgery (re-SRS).

Methods For this study, we used our database, which included 804 patients who underwent gamma knife re-SRS during the period 1998-2013.

Conclusions Among the 5 systems, based on patient number proportions, MST separation among the 3/4 groups, and/or detailed reflection of status changes, the Modified-RPA system was shown to be most applicable to re-SRS patients.

Results There were statistically significant survival differences among patients stratified into 3 or 4 groups based on the 5 systems (P < 0.001). With RPA, SIR, BSBM, and the Modified-RPA, there were statistically significant median survival time (MST) differences between any 2 pairs within the 3/4 groups. With the GPA system, however, the MST difference between the GPA 3.5-4.0 and GPA 3.0 groups did not reach statistical significance (P = 0.48). There were large patient number discrepancies among the 3/4 groups in the RPA, SIR, BSBM, and GPA whereas patient numbers were very similar among the 3 Modified-RPA system groups. Our present results show the RPA and BSBM systems to reflect changes less well, with 86%-95% of patients remaining in the same categories between the first and second SRS procedures. However, with SIR, GPA, and the Modified-RPA, 25%-31% of patients were categorized into different subclasses, either better or worse. With the modified-RPA system, such categorical change correlated well with post-re-SRS MSTs.

ジャーナルWorld neurosurgery
出版ステータスPublished - 2014 12月 1

ASJC Scopus subject areas

  • 外科
  • 臨床神経学


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