Visualization of Myelin for the Diagnosis and Treatment Monitoring of Multiple Sclerosis

研究成果: Article査読

1 被引用数 (Scopus)

抄録

Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS) affecting more than two million people worldwide. As the exact etiology of MS remains elusive, the diagnosis of MS is made by referring to the McDonald diagnostic criteria, which utilizes MRI as a tool to identify "demyelinated" MS lesions. In particular, hyperintense lesions on T2-weighted images (T2WI) or so-called "T2-lesions" are considered to represent demyelinated MS lesions. T2WI, however, lacks myelin specificity, and moreover, remyelination could not be depicted by the use of such modality. For the accurate diagnosis and treatment decision-making, or for the future development of remyelination therapeutics, imaging tools to visualize myelin-specific signals are mandatory. In this chapter, the current use and the limitation of imaging modalities in MS diagnosis and treatment will be reviewed, with the introduction of new imaging method, namely q-space Myelin Map (qMM), to be used for visualization of demyelination and remyelination in MS.

本文言語English
ページ(範囲)249-256
ページ数8
ジャーナルAdvances in experimental medicine and biology
1190
DOI
出版ステータスPublished - 2019 1月 1

ASJC Scopus subject areas

  • 生化学、遺伝学、分子生物学一般

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