Volume transmission signalling via astrocytes

Hajime Hirase, Youichi Iwai, Norio Takata, Yoshiaki Shinohara, Tsuneko Mishima

研究成果: Review article査読

43 被引用数 (Scopus)


The influence of astrocytes on synaptic function has been increasingly studied, owing to the discovery of both gliotransmission and morphological ensheathment of synapses. While astrocytes exhibit at best modest membrane potential fluctuations, activation of G-protein coupled receptors (GPCRs) leads to a prominent elevation of intracellular calcium which has been reported to correlate with gliotransmission. In this review, the possible role of astrocytic GPCR activation is discussed as a trigger to promote synaptic plasticity, by affecting synaptic receptors through gliotransmitters. Moreover, we suggest that volume transmission of neuromodulators could be a biological mechanism to activate astrocytic GPCRs and thereby to switch synaptic networks to the plastic mode during states of attention in cerebral cortical structures.

ジャーナルPhilosophical Transactions of the Royal Society B: Biological Sciences
出版ステータスPublished - 2014 10月 19

ASJC Scopus subject areas

  • 生化学、遺伝学、分子生物学一般
  • 農業および生物科学一般


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