@inbook{79f799e7567242229f8928cd95bb2ee6,
title = "Water Biology in Human Body",
abstract = "Seventy percent of our body is composed of water. Magnetic resonance imaging has become widely applied in medicine because of the high water content in the human body. Water balance is dynamically and precisely regulated. The discovery of the water channel aquaporin (AQP) has made it possible to understand water dynamics at cellular and molecular levels. AQP plays important roles not only in epithelial fluid secretion and absorption, but also in cell volume regulation and cell migration. By proposing a new concept known as 'water biology,' an attempt is made to revisit human physiology and pathology from the aspect of water molecule dynamics in the body.",
keywords = "Aquaporin (AQP), Body water content, Brain edema, Cell volume regulation, Diseases, Extracellular space (ECS), Knockout mice, Magnetic resonance imaging (MRI), Water biology, Water permeability",
author = "M. Yasui",
note = "Funding Information: 1998: Human Frontier Science Program, Long-term Fellowship Award, American Heart Association MDA Fellowship Award Funding Information: Masato Yasui graduated from School of Medicine, Keio University (Tokyo, Japan) with Medical License (M.D.) in 1989. He obtained Doctor of philosophy (Ph.D.) at the Karolinska Institute (Stockholm, Sweden) in 1997 (thesis title: Expression and Regulation of water channels and ion transpoters (Ontogenic Aspects)) and Doctor of medical science (Ph.D.) at School of Medicine, Keio University (Tokyo, Japan) in 1998. In clinical training : Yasui was a clinical resident of pediatrics in St. Luke's International Hospital, Tokyo, Japan (1989–1992), and Clinical Fellow of Neonatology in Tokyo Women's Medical University, Tokyo, Japan (1992). In research training : Yasui was a guest researcher in Department of Molecular Neurobiology, University of Tokyo, Tokyo, Japan, with Prof. Katsuhiko Mikoshiba in 1992. He was a postgraduate student in the Department of Woman and Child Health, Pediatric Unit, Karolinska Institute, Stockholm, Sweden with Prof. Anita Aperia (1993–1997). He was a Postdoctoral Research Fellow in the Department of Biological Chemistry, Johns Hopkins University, School of Medicine, Baltimore, USA, with Prof. Peter Agre from 1997 to 2000. Academic positions : From 2000 to 2001, Yashi was an instructor in the Department of Biological Chemistry, Johns Hopkins School of Medicine, Baltimore, Maryland, USA. Since 2001, he became an assistant professor of Departments of Pediatrics and Biological Chemistry, Johns Hopkins School of Medicine, Baltimore, Maryland, USA. He is now professor and chair of Department of Pharmacology, Keio University School of Medicine, Tokyo, Japan since 2006. Masato Yasui has been awarded the following honors : Sasakawa Scandinavia-Japan Research Foundation (1993), Society for Pediatric Research, Student Award (1997), Human Frontier Science Program, Long-term Fellowship Award (1998), American Heart Association MDA Fellowship Award (1998), Johns Hopkins Young Investigators Day (2000), A. McGehee Harvey Prize for Postdoctoral research (2000), Keio Medical School, Alumni Association Award, Tokyo (2002), Biennial Spa Foundation Prize (shared with Peter Agre), Brussels (2003), and S&R Foundation Award, Washington, D.C. (2004). Publisher Copyright: {\textcopyright} 2014 Elsevier B.V. All rights reserved.",
year = "2014",
month = jul,
day = "25",
doi = "10.1016/B978-0-444-53632-7.01007-8",
language = "English",
isbn = "9780444536334",
volume = "10",
pages = "83--89",
booktitle = "Physical Medicine and Rehabilitation",
publisher = "Elsevier",
}
