What Can We Tell About the Effect of Electroconvulsive Therapy on the Human Hippocampus?

Akihiro Takamiya, Taishiro Kishimoto, Masaru Mimura

研究成果: Article査読

1 被引用数 (Scopus)

抄録

Electroconvulsive therapy (ECT) is the most effective antidepressant treatment, although its mechanisms of action remain unclear. Since 2010, several structural magnetic resonance imaging studies based on a neuroplastic hypothesis have consistently reported increases in the hippocampal volume following ECT. Moreover, volume increases in the human dentate gyrus, where neurogenesis occurs, have also been reported. These results are in line with the preclinical findings of ECT-induced neuroplastic changes, including neurogenesis, gliogenesis, synaptogenesis, and angiogenesis, in rodents and nonhuman primates. Despite this robust evidence of an effect of ECT on hippocampal plasticity, the clinical relevance of these human hippocampal changes continues to be questioned. This narrative review summarizes recent findings regarding ECT-induced hippocampal volume changes. Furthermore, this review also discusses methodological considerations and future directions in this field.

本文言語English
ページ(範囲)584-593
ページ数10
ジャーナルClinical EEG and Neuroscience
54
6
DOI
出版ステータスPublished - 2023 11月
外部発表はい

ASJC Scopus subject areas

  • 神経学
  • 臨床神経学

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