抄録
METHOD: Three specific developments in the field of schizophrenia are highlighted: advances in knowledge related to the earliest stages of schizophrenia, specifically the prodrome; reconceptualization of schizophrenia as an illness of multiple symptom domains; and greater clarification regarding the efficacy of clozapine and a new generation of APs.
RESULTS: Evidence indicating that negative and cognitive symptoms are present during the prodrome suggests that intervention at the time of first-episode psychosis constitutes late intervention. The limited efficacy of APs beyond psychosis argues against a magic bullet approach to schizophrenia and for polypharmacy that is symptom domain-specific. Clozapine's unique, but limited, efficacy in treatment resistance supports subtyping schizophrenia based on treatment response.
CONCLUSIONS: Advances in our understanding of schizophrenia have important implications regarding the current use of APs, expectations regarding response, and future drug development.
OBJECTIVE: To examine how advances in our understanding of schizophrenia have shaped thinking about antipsychotics (APs) and their role in treatment.
| 本文言語 | English |
|---|---|
| ページ（範囲） | S14-S18 |
| ジャーナル | Canadian journal of psychiatry. Revue canadienne de psychiatrie |
| 巻 | 60 |
| 号 | 3 |
| 出版ステータス | Published - 2015 3月 1 |
| 外部発表 | はい |
ASJC Scopus subject areas
- 精神医学および精神衛生
UN SDG
この成果は、次の持続可能な開発目標に貢献しています
