White matter microstructural organizations in patients with severe treatment-resistant schizophrenia: A diffusion tensor imaging study

Ryo Ochi, Yoshihiro Noda, Shohei Tsuchimoto, Ryosuke Tarumi, Shiori Honda, Karin Matsushita, Sakiko Tsugawa, Eric Plitman, Fumi Masuda, Kamiyu Ogyu, Masataka Wada, Takahiro Miyazaki, Shinya Fujii, M. Mallar Chakravarty, Ariel Graff-Guerrero, Hiroyuki Uchida, Masaru Mimura, Shinichiro Nakajima

研究成果: Article査読

19 被引用数 (Scopus)


Previous diffusion tensor imaging (DTI) studies have reported white matter alterations in patients with schizophrenia. Notably, one third of this population does not respond to first-line antipsychotics and is thus referred to as treatment-resistant schizophrenia (TRS). Despite potentially distinct neural bases between TRS and non-TRS, few studies have compared white matter integrity between these groups. In order to reflect clinical picture of TRS, we enrolled TRS patients who had severe symptoms. According to the consensus criteria for TRS. TRS was defined by severe positive symptomatology despite optimal antipsychotic treatment. Fractional anisotropy (FA), an index of white matter integrity, was examined by DTI and analyzed with tract-based spatial statistics in 24 TRS patients (mean PANSS = 108.9), 28 non-TRS patients (mean PANSS = 50.0), and 27 healthy controls (HCs) for group comparison. Additionally, correlation analyses were conducted between FA values and symptomatology. The TRS group had lower FA values in multiple tracts (cerebral peduncle, corona radiata, corpus callosum, external and internal capsules, posterior thalamic radiation, sagittal stratum, superior longitudinal fasciculus, tapetum, and uncinate fasciculus) compared to the HC group as well as the non-TRS group (p <.05; family-wise error-corrected), while no differences were found between the non-TRS and HC groups. In the TRS group, FA values in most of the tracts (other than the left anterior limb of internal capsule, left cerebral peduncle, and right uncinate fasciculus) were negatively correlated with the Positive and Negative Syndrome Scale total scores, and negative and general symptom scores. No such relationships were found in the non-TRS group. The identified white matter integrity deficits may reflect the pathophysiology of TRS.

ジャーナルProgress in Neuro-Psychopharmacology and Biological Psychiatry
出版ステータスPublished - 2020 6月 8

ASJC Scopus subject areas

  • 薬理学
  • 生物学的精神医学


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