TY - JOUR
T1 - Whole-cell simulation
T2 - A grand challenge of the 21st century
AU - Tomita, Masaru
N1 - Funding Information:
We thank Koichi Takahashi, Kenta Hashimoto and Yoichi Nakayama for their leaderships in developing the basic E-CELL software, the Virtual Self-Surviving Cell Model, and the Human Erythrocyte Model, respectively. Special thanks are extended to many other colleagues in the Laboratory for Bioinformatics of Keio University, including Yuri Matsuzaki, Katsuyuki Yugi, Fumihiko Miyoshi, Yusuke Saito and Naota Ishikawa, for their dedication to the E-CELL project. The author acknowledges the support of Japan Science and Technology Corporation (JST) and the Ministry of Education, Japan.
PY - 2001/6/1
Y1 - 2001/6/1
N2 - Study of the cell will never be complete unless its dynamic behavior is understood. The complex behavior of the cell cannot be determined or predicted unless a computer model of the cell is constructed and computer simulation is undertaken. Rapid accumulation of biological data from genome, proteome, transcriptome and metabolome projects can bring us to the point where it is no longer purely speculative to discuss how to construct virtual cells in silico. This article describes attempts to construct whole cell models. The E-CELL project has completed a couple of virtual cell models, and computer simulations have revealed some biological surprises.
AB - Study of the cell will never be complete unless its dynamic behavior is understood. The complex behavior of the cell cannot be determined or predicted unless a computer model of the cell is constructed and computer simulation is undertaken. Rapid accumulation of biological data from genome, proteome, transcriptome and metabolome projects can bring us to the point where it is no longer purely speculative to discuss how to construct virtual cells in silico. This article describes attempts to construct whole cell models. The E-CELL project has completed a couple of virtual cell models, and computer simulations have revealed some biological surprises.
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U2 - 10.1016/S0167-7799(01)01636-5
DO - 10.1016/S0167-7799(01)01636-5
M3 - Review article
C2 - 11356281
AN - SCOPUS:0035371624
SN - 0167-7799
VL - 19
SP - 205
EP - 210
JO - Trends in Biotechnology
JF - Trends in Biotechnology
IS - 6
ER -