Wnt Signaling in the Niche

Toshio Suda; Fumio Arai

doi:10.1016/j.cell.2008.02.017

Wnt Signaling in the Niche

Toshio Suda, Fumio Arai

研究成果: Short survey › 査読

43 被引用数 (Scopus)

抄録

There is much interest in understanding the signals in the bone marrow niche that keep hematopoietic stem cells (HSCs) in a quiescent state. In the current issue of Cell Stem Cell, Fleming et al. (2008) report that blocking Wnt signaling in the niche increases the number of proliferating HSCs and reduces their ability to reconstitute the hematopoietic system of irradiated recipient mice. These findings show that Wnt/β-catenin activity is crucial for the maintenance of HSC quiescence in the bone marrow niche.

本文言語	English
ページ（範囲）	729-730
ページ数	2
ジャーナル	Cell
巻	132
号	5
DOI	https://doi.org/10.1016/j.cell.2008.02.017
出版ステータス	Published - 2008 3月 7
外部発表	はい

ASJC Scopus subject areas

生化学、遺伝学、分子生物学（全般）

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10.1016/j.cell.2008.02.017

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引用スタイル

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Wnt Signaling in the Niche

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